Technology Process of [5-(2-Chloro-benzyl)-2-ethyl-4,5,6,7-tetrahydro-thieno[3,2-c]pyridin-3-yl]-[4-(2-dimethylamino-ethoxy)-phenyl]-methanone
There total 6 articles about [5-(2-Chloro-benzyl)-2-ethyl-4,5,6,7-tetrahydro-thieno[3,2-c]pyridin-3-yl]-[4-(2-dimethylamino-ethoxy)-phenyl]-methanone which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1.) BuLi, HMPT / 1.) THF, 0 deg C, 1 h, 2.) THF, RT, overnight
2: 82 percent / NaBH4, trifluoroacetic acid / CH2Cl2 / 3 h / Ambient temperature
3: 32 percent / SnCl4 / CH2Cl2 / 20 h / Ambient temperature
4: 40 percent / 48percent aq. HBr, acetic acid / 4 h / 80 °C
5: 1.) K2CO3 / 1.) water, CH2Cl2, reflux, 1 h, 2.) water, CH2Cl2, reflux, 4 h
With
N,N,N,N,N,N-hexamethylphosphoric triamide; sodium tetrahydroborate; n-butyllithium; hydrogen bromide; tin(IV) chloride; potassium carbonate; acetic acid; trifluoroacetic acid;
In
dichloromethane;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 32 percent / SnCl4 / CH2Cl2 / 20 h / Ambient temperature
2: 40 percent / 48percent aq. HBr, acetic acid / 4 h / 80 °C
3: 1.) K2CO3 / 1.) water, CH2Cl2, reflux, 1 h, 2.) water, CH2Cl2, reflux, 4 h
With
hydrogen bromide; tin(IV) chloride; potassium carbonate; acetic acid;
In
dichloromethane;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 82 percent / NaBH4, trifluoroacetic acid / CH2Cl2 / 3 h / Ambient temperature
2: 32 percent / SnCl4 / CH2Cl2 / 20 h / Ambient temperature
3: 40 percent / 48percent aq. HBr, acetic acid / 4 h / 80 °C
4: 1.) K2CO3 / 1.) water, CH2Cl2, reflux, 1 h, 2.) water, CH2Cl2, reflux, 4 h
With
sodium tetrahydroborate; hydrogen bromide; tin(IV) chloride; potassium carbonate; acetic acid; trifluoroacetic acid;
In
dichloromethane;
