Technology Process of 2-(2,6-dichlorophenyl)-2,3,5,6-tetrahydro-1H-imidazo<1,2-a>imidazole
There total 8 articles about 2-(2,6-dichlorophenyl)-2,3,5,6-tetrahydro-1H-imidazo<1,2-a>imidazole which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 94 percent / methanol; H2O / 5 h / Ambient temperature
2: 93 percent / LiAlH4 / diethyl ether / 1.) 0-10 deg C, 5 h; 2.) RT, overnight
3: 43 percent / 1.) 100-120 deg C, 30 min; 2.) 190-210 deg C, 30 min
4: 74 percent / 50 percent NaH / dimethylformamide / 1.) RT, 1 h; 2.) 5 h
5: 1.) cc. HCl; 2.) SOCl2; 3.) KOH, H2O, MeOH / 1.) reflux, 6 h; 2.) RT, 2 h; 3.) reflux, 5 h
With
hydrogenchloride; methanol; potassium hydroxide; lithium aluminium tetrahydride; thionyl chloride; water; sodium hydride;
In
methanol; diethyl ether; water; N,N-dimethyl-formamide;
DOI:10.1248/cpb.33.2838
- Guidance literature:
-
Multi-step reaction with 3 steps
2: 92 percent / benzene / 3 h / Ambient temperature
3: 1.) SOCl2; 2.) KOH, H2O, MeOH / 1.) RT, 2 h; 2.) reflux, 5 h
With
methanol; potassium hydroxide; thionyl chloride; water;
In
benzene;
DOI:10.1248/cpb.33.2838
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 92 percent / benzene / 3 h / Ambient temperature
2: 1.) SOCl2; 2.) KOH, H2O, MeOH / 1.) RT, 2 h; 2.) reflux, 5 h
With
methanol; potassium hydroxide; thionyl chloride; water;
In
benzene;
DOI:10.1248/cpb.33.2838
