Technology Process of (1S)-1,5-anhydro-2,3,4,6-tetra-O-benzyl-1-[2-(benzyloxy)-4-methyl-5-[4-[2-(tritylamino)ethyl]benzyl]phenyl]-D-glucitol
There total 11 articles about (1S)-1,5-anhydro-2,3,4,6-tetra-O-benzyl-1-[2-(benzyloxy)-4-methyl-5-[4-[2-(tritylamino)ethyl]benzyl]phenyl]-D-glucitol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
triethylsilane; boron trifluoride diethyl etherate;
In
chloroform; acetonitrile;
at 0 ℃;
DOI:10.1016/j.bmcl.2018.09.035
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: potassium carbonate; tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide / 20 °C
2.1: sodium bromide; Oxone / acetone; water / 20 °C
3.1: oxalyl dichloride; N,N-dimethyl-formamide / chloroform / 20 °C
3.2: 20 °C
3.3: 0 °C
4.1: toluene-4-sulfonic acid / toluene / Reflux
5.1: n-butyllithium / tetrahydrofuran / -78 °C
6.1: hydrogenchloride / water; tetrahydrofuran
7.1: n-butyllithium / tetrahydrofuran
7.2: -78 °C
8.1: triethylsilane; boron trifluoride diethyl etherate / chloroform; acetonitrile / 0 °C
With
hydrogenchloride; triethylsilane; Oxone; n-butyllithium; oxalyl dichloride; boron trifluoride diethyl etherate; tetra-(n-butyl)ammonium iodide; potassium carbonate; toluene-4-sulfonic acid; N,N-dimethyl-formamide; sodium bromide;
In
tetrahydrofuran; chloroform; water; N,N-dimethyl-formamide; acetone; toluene; acetonitrile;
DOI:10.1016/j.bmcl.2018.09.035
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: n-butyllithium / tetrahydrofuran / -78 °C
2.1: hydrogenchloride / water; tetrahydrofuran
3.1: n-butyllithium / tetrahydrofuran
3.2: -78 °C
4.1: triethylsilane; boron trifluoride diethyl etherate / chloroform; acetonitrile / 0 °C
With
hydrogenchloride; triethylsilane; n-butyllithium; boron trifluoride diethyl etherate;
In
tetrahydrofuran; chloroform; water; acetonitrile;
DOI:10.1016/j.bmcl.2018.09.035
