102987-40-6Relevant articles and documents
Compound of dipyrrolopyridine structure Preparation method and medical application
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Paragraph 0147-0150, (2021/08/25)
The invention discloses a compound with a dipyrrolo-pyridine structure as well as a preparation method and medical application thereof. The compound provided by the invention has obvious inhibitory activity on JAK family proteins, is an effective JAK inhibitor, and has the prospect of being developed into drugs for inhibiting JAK and further treating diseases.
Enantioselective Synthesis of the Tricyclic Core of FR901483 Featuring a Rhodium-Catalyzed [2+2+2] Cycloaddition
Perreault, Stéphane,Rovis, Tomislav
, p. 719 - 728 (2013/04/23)
An efficient approach to the tricyclic framework of FR901483 is described. The sequence features a [3,3]-sigmatropic rearrangement of a cyanate to an isocyanate, followed by its subsequent asymmetric rhodium-catalyzed [2+2+2] cycloaddition with a terminal
Cobalt-catalyzed benzyl-alkynyl coupling
Kuno, Akiko,Saino, Naoko,Kamachi, Taku,Okamoto, Sentaro
, p. 2591 - 2594 (2007/10/03)
Benzylic halides coupled with 1-alkynylmagnesium halides in the presence of a catalytic amount of Co(acac)3 to provide 1-aryl-2-alkynes in moderate to good yield.