3,4-Dimethoxybenzohydroxamic acid

Base Information

• Chemical Name: 3,4-Dimethoxybenzohydroxamic acid
• CAS No.: 13546-91-3
• Molecular Formula: C9H11NO4
• Molecular Weight: 197.191
• DSSTox Substance ID: DTXSID30436318
• Nikkaji Number: J359.238C
• Wikidata: Q82251588
• Mol file: 13546-91-3.mol

Synonyms:3,4-dimethoxybenzohydroxamic acid;13546-91-3;SCHEMBL1436474;DTXSID30436318;JNGOJCZYTKJSQV-UHFFFAOYSA-N;AKOS000185536

Chemical Property of 3,4-Dimethoxybenzohydroxamic acid

Chemical Property:

• XLogP3: 0.9
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 197.06880783
• Heavy Atom Count: 14
• Complexity: 197

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=C(C=C(C=C1)C(=O)NO)OC

Technology Process of 3,4-Dimethoxybenzohydroxamic acid

There total 7 articles about 3,4-Dimethoxybenzohydroxamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

3,4-dimethoxybenzoic acid chloride (3535-37-3) → N-hydroxy-3,4-dimethoxybenzamide (13546-91-3)

Guidance literature:

With hydroxylamine hydrochloride; sodium hydrogencarbonate; In water; ethyl acetate; at 20 ℃; for 0.0833333h;

Reference yield: 80.0%

(3,4-dimethoxy-phenyl)-glyoxylonitrile (65961-86-6) → N-hydroxy-3,4-dimethoxybenzamide (13546-91-3)

Guidance literature:

With hydroxylamine;

DOI:10.1016/S0040-4039(00)87114-2

Reference yield: 77.0%

ethyl veratrate (3943-77-9) → N-hydroxy-3,4-dimethoxybenzamide (13546-91-3)

Guidance literature:

With potassium hydroxide; hydroxylamine hydrochloride; In methanol; for 36h; Ambient temperature;

DOI:10.1055/s-1987-27874

upstream raw materials:

(3,4-dimethoxy-phenyl)-glyoxylonitrile

ethyl veratrate

3,4-Dimethoxy-benzaldehyde oxime

3,4-dimethoxybenzoic acid chloride

Downstream raw materials:

3,4-dimethoxyaniline

3,4-(dimethoxy)-N-(pivaloyloxy)benzamide

N-(3,4-dimethoxyphenyl)formamide

veratronitrile

Refernces

• 1、 Jia, Mengmeng,Zhang, Heng,Lin, Yongjia,Chen, Dimei,Chen, Yanmei,Xia, Yuanzhi. "Consecutive Lossen rearrangement/transamidation reaction of hydroxamic acids under catalyst- and additive-free conditions". . p. 3615 - 3624. Retrieved 2018/05/26.
• 2、 Fakhruddin, Ahmad,Abu-Elfotoh, Abdel-Moneim,Shibatomi, Kazutaka,Iwasa, Seiji. "A new synthetic route to acylnitroso intermediates and their applications in HDA and ene reactions". supporting information. p. 196 - 205. Retrieved 2018/03/09.