sodium (βR*,γS*)-4-<<3-(4-acetyl-3-hydroxy-2-propylphenoxy)propyl>thio>-γ-hydroxy-β-methylbenzenebutanoate

Base Information

• Chemical Name: sodium (βR*,γS*)-4-<<3-(4-acetyl-3-hydroxy-2-propylphenoxy)propyl>thio>-γ-hydroxy-β-methylbenzenebutanoate
• CAS No.: 100443-69-4
• Molecular Formula: C₂₅H₃₁O₆S*Na
• Molecular Weight: 482.573
• Mol file: 100443-69-4.mol

Synonyms:

Chemical Property of sodium (βR*,γS*)-4-<<3-(4-acetyl-3-hydroxy-2-propylphenoxy)propyl>thio>-γ-hydroxy-β-methylbenzenebutanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of sodium (βR*,γS*)-4-<<3-(4-acetyl-3-hydroxy-2-propylphenoxy)propyl>thio>-γ-hydroxy-β-methylbenzenebutanoate

There total 23 articles about sodium (βR*,γS*)-4-<<3-(4-acetyl-3-hydroxy-2-propylphenoxy)propyl>thio>-γ-hydroxy-β-methylbenzenebutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(4S,5R)-5-{4-[3-(4-Acetyl-3-hydroxy-2-propyl-phenoxy)-propylsulfanyl]-phenyl}-4-methyl-dihydro-furan-2-one (91584-73-5,100443-70-7,100443-74-1,115114-74-4,115114-75-5) → sodium (βR*,γS*)-4-<<3-(4-acetyl-3-hydroxy-2-propylphenoxy)propyl>thio>-γ-hydroxy-β-methylbenzenebutanoate (100443-69-4)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; methanol;

DOI:10.1021/jm00159a003

Reference yield:

4-<(3-bromopropyl)oxy>-2-hydroxy-3-propylacetophenone (40786-20-7) → Sodium; 4-{4-[3-(4-acetyl-3-hydroxy-2-propyl-phenoxy)-propylsulfanyl]-phenyl}-4-hydroxy-3-methyl-butyrate (91541-76-3,91541-81-0,91541-85-4,91584-72-4,100443-69-4,103365-84-0)

Guidance literature:

Multi-step reaction with 3 steps

1: K₂CO₃ / butan-2-one / 4 h / Heating

2: NaOH / methanol; tetrahydrofuran

With sodium hydroxide; potassium carbonate; In tetrahydrofuran; methanol; butanone;

DOI:10.1021/jm00159a003

Reference yield:

4-<(3-bromopropyl)oxy>-2-hydroxy-3-propylacetophenone (40786-20-7) → sodium (βR*,γS*)-4-<<3-(4-acetyl-3-hydroxy-2-propylphenoxy)propyl>thio>-γ-hydroxy-β-methylbenzenebutanoate (100443-69-4)

Guidance literature:

Multi-step reaction with 2 steps

1: K₂CO₃ / butan-2-one / 4 h / Heating

2: NaOH / methanol; tetrahydrofuran

With sodium hydroxide; potassium carbonate; In tetrahydrofuran; methanol; butanone;

DOI:10.1021/jm00159a003

upstream raw materials:

4-<(3-bromopropyl)oxy>-2-hydroxy-3-propylacetophenone

3-(4-hydroxybenzoyl)propionic acid

methoxybenzene

4-dimethylthiocarbamoyloxygamma-oxobenzenebutanoic acid,methyl ester

Downstream raw materials:

Sodium; 4-{4-[3-(4-acetyl-3-hydroxy-2-propyl-phenoxy)-propylsulfanyl]-phenyl}-4-hydroxy-3-methyl-butyrate

Sodium; 4-{4-[3-(4-acetyl-3-hydroxy-2-propyl-phenoxy)-propylsulfanyl]-phenyl}-4-hydroxy-3-methyl-butyrate