3-[2-(N'-{3-[3-((R)-1-Methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-ureido]-benzyl}-guanidino)-thiazol-4-ylmethylsulfanyl]-propionimidic acid methyl ester

Base Information

Chemical Name:3-[2-(N'-{3-[3-((R)-1-Methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-ureido]-benzyl}-guanidino)-thiazol-4-ylmethylsulfanyl]-propionimidic acid methyl ester
CAS No.:187817-05-6
Molecular Formula:C₃₃H₃₅N₉O₃S₂
Molecular Weight:669.831
Hs Code.:

3-[2-(N'-{3-[3-((R)-1-Methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-ureido]-benzyl}-guanidino)-thiazol-4-ylmethylsulfanyl]-propionimidic acid methyl ester

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Chemical Property of 3-[2-(N'-{3-[3-((R)-1-Methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-ureido]-benzyl}-guanidino)-thiazol-4-ylmethylsulfanyl]-propionimidic acid methyl ester

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Technology Process of 3-[2-(N'-{3-[3-((R)-1-Methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-ureido]-benzyl}-guanidino)-thiazol-4-ylmethylsulfanyl]-propionimidic acid methyl ester

There total 4 articles about 3-[2-(N'-{3-[3-((R)-1-Methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-ureido]-benzyl}-guanidino)-thiazol-4-ylmethylsulfanyl]-propionimidic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 67-56-1
methanol

: 187816-98-4
(+)-(R)-1-(3-{N'-[4-(2-cyanoethylthiomethyl)thiazol-2-yl]guanidinomethyl}phenyl)-3-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)urea

: 187817-05-6
3-[2-(N'-{3-[3-((R)-1-Methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-ureido]-benzyl}-guanidino)-thiazol-4-ylmethylsulfanyl]-propionimidic acid methyl ester

Guidance literature:: With hydrogenchloride; for 72h;
DOI:10.1248/cpb.45.116

Reference yield:

: 76823-92-2
3-<<<2-(S-methylisithioureido)-4-thiazolyl>methyl>thio>propionitrile hydroiodide

: 187817-05-6
3-[2-(N'-{3-[3-((R)-1-Methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-ureido]-benzyl}-guanidino)-thiazol-4-ylmethylsulfanyl]-propionimidic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 73 percent / ethanol / 20 h / Heating

2: CH₂Cl₂ / 2 h / Ambient temperature

3: 92 percent / HCl gas / 72 h

With hydrogenchloride; In ethanol; dichloromethane;
DOI:10.1248/cpb.45.116

Reference yield:

: (R)-3-Amino-1-methyl-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one; compound with (7,7-dimethyl-2-oxo-bicyclo[2.2.1]hept-1-yl)-methanesulfonic acid

: 187817-05-6
3-[2-(N'-{3-[3-((R)-1-Methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-ureido]-benzyl}-guanidino)-thiazol-4-ylmethylsulfanyl]-propionimidic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: CH₂Cl₂

2: CH₂Cl₂ / 2 h / Ambient temperature

3: 92 percent / HCl gas / 72 h

With hydrogenchloride; In dichloromethane;
DOI:10.1248/cpb.45.116