5(4H)-Oxazolone, 2-phenyl-4,4-bis(phenylmethyl)-

Base Information

• Chemical Name: 5(4H)-Oxazolone, 2-phenyl-4,4-bis(phenylmethyl)-
• CAS No.: 135906-34-2
• Molecular Formula: C23H19NO2
• Molecular Weight: 341.409
• DSSTox Substance ID: DTXSID90459982
• Nikkaji Number: J1.981.381I
• Mol file: 135906-34-2.mol

Synonyms:5(4H)-Oxazolone, 2-phenyl-4,4-bis(phenylmethyl)-;135906-34-2;DTXSID90459982;4,4-Dibenzyl-2-phenyloxazol-5(4H)-one;2-Phenyl-4,4-dibenzyl-2-oxazoline-5-one;CS-0374566;4,4-dibenzyl-2-phenyl-1,3-oxazol-5(4h)-one

Chemical Property of 5(4H)-Oxazolone, 2-phenyl-4,4-bis(phenylmethyl)-

Chemical Property:

• XLogP3: 5.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 341.141578849
• Heavy Atom Count: 26
• Complexity: 488

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)CC2(C(=O)OC(=N2)C3=CC=CC=C3)CC4=CC=CC=C4

Technology Process of 5(4H)-Oxazolone, 2-phenyl-4,4-bis(phenylmethyl)-

There total 12 articles about 5(4H)-Oxazolone, 2-phenyl-4,4-bis(phenylmethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-benzyl-2-phenyl-2-oxazolin-5-one (5874-61-3,21453-79-2,51127-19-6,75658-67-2) + benzyl bromide (100-39-0) → 4,4-dibenzyl-2-phenyl-1,3-oxazol-5(4H)-one (135906-34-2)

Guidance literature:

With 2-tert-butylimino-2-diethylamino-1,3-dimethyl-perhydro-1,3,2-diazaphosphorine; In tetrahydrofuran; at 20 ℃; for 0.0166667h;

DOI:10.1055/s-0032-1317801

Reference yield: 79.0%

N-benzoyl-N-(4-methoxybenzyl)-α,α-dibenzylglycine 4-methoxybenzyl amide (658044-04-3) → N-benzoyl-α,α-dibenzylglycine (54132-09-1) + 4,4-dibenzyl-2-phenyl-1,3-oxazol-5(4H)-one (135906-34-2)

Guidance literature:

With trifluoroacetic acid; for 0.166667h; Heating;

DOI:10.1039/b307111c

Reference yield: 76.0%

N-benzoyl-N-(4-methoxybenzyl)-α,α-dibenzylglycine cyclohexyl amide (658044-06-5) → 4,4-dibenzyl-2-phenyl-1,3-oxazol-5(4H)-one (135906-34-2) + N-benzoyl-N-(4-methoxybenzyl)-α,α-dibenzylglycine

Guidance literature:

With trifluoroacetic acid; In acetonitrile; at 20 ℃; for 12h;

DOI:10.1039/b307111c

upstream raw materials:

4-benzyl-2-phenyl-2-oxazolin-5-one

benzyl bromide

N-benzoyl-α,α-dibenzylglycine cyclohexylamide

N-benzoyl-N-(4-methoxybenzyl)-α,α-dibenzylglycine cyclohexyl amide

Downstream raw materials:

2-amino-2-benzyl-3-phenylpropanoic acid

N-benzoyl-α,α-dibenzylglycine