(Rp)-ortho-(diphenylphosphanyl)ferrocenylcarboxylic acid

Base Information

Chemical Name:(Rp)-ortho-(diphenylphosphanyl)ferrocenylcarboxylic acid
CAS No.:297176-74-0
Molecular Formula:C₂₃H₁₉FeO₂P
Molecular Weight:414.223
Hs Code.:

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Chemical Property of (Rp)-ortho-(diphenylphosphanyl)ferrocenylcarboxylic acid

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Technology Process of (Rp)-ortho-(diphenylphosphanyl)ferrocenylcarboxylic acid

There total 4 articles about (Rp)-ortho-(diphenylphosphanyl)ferrocenylcarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: (S,Sp)-2-(diphenylphosphino)-[1-(N-acetyl)-2-tert-butyl-2-amino ethoxycarbonyl]-1-ferrocene

: 677722-99-5,847675-62-1,297176-74-0
(Sp)-ortho-(diphenylphosphanyl)ferrocenylcarboxylic acid

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; methanol; under Ar to soln. of Fe-complex in THF-MeOH NaOH was added, refluxed for2 h, cooled to room temp.; solvent was removed, HCl was added to pH 1, extd. with CH2Cl2, organic layer was dried, solvent was removed in vacuo, column chromy. with EtOAc--petroleum ether; elem. anal.;
DOI:10.1016/S0022-328X(01)01143-3

Reference yield: 93.0%

: (S,Sp)-2-acetamido-3-methylbutyl 2-(diphenylphosphino)ferrocenecarboxylate

: 297176-74-0,847675-62-1,677722-99-5
(Sp)-2-(diphenylphosphino)ferrocenecarboxylic acid

: 1083100-07-5
methyl (Sp)-2-(diphenylphosphino)ferrocenecarboxylate

Guidance literature:: With aq. NaOH; In tetrahydrofuran; methanol; all manipulations under Ar; Fe compd. dissolved in mixt. of THF and MeOH, aq. NaOH soln. added, stirred at 50°C overnight; solvent removed, 3 M HCl added, extd. with CH2Cl2, washed with water, dried with MgSO4, evapd., chromy. (silica gel, CH2Cl2-MeOH (20:1)), evapd.dried in vac. (1 Torr, 60°C, 1 h), elem. anal.; Me-compd. identi fied by NMR;
DOI:10.1039/b109495p

Reference yield: 58.0%

: (R,Rp)-Phosferrox

: 847675-62-1,297176-74-0,677722-99-5
(Rp)-ortho-(diphenylphosphanyl)ferrocenylcarboxylic acid

Guidance literature:: (R,Rp)-Phosferrox; With sodium sulfate; trifluoroacetic acid; In tetrahydrofuran; water; for 72h;

With potassium hydroxide; In methanol; for 2h; Reflux;
DOI:10.1021/jacs.0c11504