C₂₃H₂₅ClF₂O₅S₂

Base Information

• Chemical Name: C₂₃H₂₅ClF₂O₅S₂
• CAS No.: 1402428-46-9
• Molecular Formula: C₂₃H₂₅ClF₂O₅S₂
• Molecular Weight: 519.03
• Mol file: 1402428-46-9.mol

Synonyms:

Chemical Property of C₂₃H₂₅ClF₂O₅S₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₃H₂₅ClF₂O₅S₂

There total 7 articles about C₂₃H₂₅ClF₂O₅S₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-sulfanylpropanol (19721-22-3) + C27H25ClF2O7S2 (1100361-35-0) → C23H25ClF2O5S2 (1402428-46-9)

Guidance literature:

With potassium hydroxide; In ethanol; at 70 ℃;

DOI:10.1016/j.bmcl.2012.11.047

Reference yield:

2-(2,3,6-trifluoro-benzylidene)-malonic acid dimethyl ester (944950-33-8) → C23H25ClF2O5S2 (1402428-46-9)

Guidance literature:

Multi-step reaction with 13 steps

1: potassium carbonate / tetrahydrofuran

2: lithium aluminium tetrahydride / tetrahydrofuran

3: potassium tert-butylate / tetrahydrofuran

4: Dess-Martin periodane / dichloromethane

5: trimethylsilyl trifluoromethanesulfonate

6: boron trifluoride diethyl etherate / dichloromethane

7: oxone / acetone; water

8: triethylamine / dichloromethane

9: potassium tert-butylate / tetrahydrofuran

10: ozone / dichloromethane

11: Resolution of racemate

12: triethylamine

13: potassium hydroxide / ethanol / 70 °C

With oxone; lithium aluminium tetrahydride; trimethylsilyl trifluoromethanesulfonate; boron trifluoride diethyl etherate; potassium tert-butylate; potassium carbonate; Dess-Martin periodane; ozone; triethylamine; potassium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; water; acetone; 1: |Michael Addition;

DOI:10.1016/j.bmcl.2012.11.047

Reference yield:

C16H13ClF2O2S → C23H25ClF2O5S2 (1402428-46-9)

Guidance literature:

Multi-step reaction with 10 steps

1: Dess-Martin periodane / dichloromethane

2: trimethylsilyl trifluoromethanesulfonate

3: boron trifluoride diethyl etherate / dichloromethane

4: oxone / acetone; water

5: triethylamine / dichloromethane

6: potassium tert-butylate / tetrahydrofuran

7: ozone / dichloromethane

8: Resolution of racemate

9: triethylamine

10: potassium hydroxide / ethanol / 70 °C

With oxone; trimethylsilyl trifluoromethanesulfonate; boron trifluoride diethyl etherate; potassium tert-butylate; Dess-Martin periodane; ozone; triethylamine; potassium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; water; acetone;

DOI:10.1016/j.bmcl.2012.11.047

upstream raw materials:

3-sulfanylpropanol

C₂₇H₂₅ClF₂O₇S₂

2-(2,3,6-trifluoro-benzylidene)-malonic acid dimethyl ester

p-Chlorothiophenol

Downstream raw materials:

C₂₃H₂₅ClF₂O₇S₂

C₂₄H₂₇ClF₂O₉S₃