[4-(2,5-Diphenyl-oxazol-4-yl)-phenoxy]-acetic acid ethyl ester

Base Information

• Chemical Name: [4-(2,5-Diphenyl-oxazol-4-yl)-phenoxy]-acetic acid ethyl ester
• CAS No.: 84671-91-0
• Molecular Formula: C₂₅H₂₁NO₄
• Molecular Weight: 399.446
• Mol file: 84671-91-0.mol

Synonyms:

Chemical Property of [4-(2,5-Diphenyl-oxazol-4-yl)-phenoxy]-acetic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [4-(2,5-Diphenyl-oxazol-4-yl)-phenoxy]-acetic acid ethyl ester

There total 6 articles about [4-(2,5-Diphenyl-oxazol-4-yl)-phenoxy]-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

sodium benzoate (532-32-1) → [4-(2,5-Diphenyl-oxazol-4-yl)-phenoxy]-acetic acid ethyl ester (84671-91-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 80 percent / conc. sulphuric acid / ethanol / 8 h / Heating

2: 74 percent / ammonium acetate / acetic acid / 1 h / Heating

3: 48 percent / 47percent HBr / acetic acid / 6 h / Heating

4: 1) K₂CO₃ / 1) acetone, reflux, 2) reflux

With ammonium acetate; sulfuric acid; hydrogen bromide; potassium carbonate; In ethanol; acetic acid;

Reference yield:

2-bromo-1-(4-methoxy-phenyl)-2-phenyl-ethanone (1889-77-6) → [4-(2,5-Diphenyl-oxazol-4-yl)-phenoxy]-acetic acid ethyl ester (84671-91-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 80 percent / conc. sulphuric acid / ethanol / 8 h / Heating

2: 74 percent / ammonium acetate / acetic acid / 1 h / Heating

3: 48 percent / 47percent HBr / acetic acid / 6 h / Heating

4: 1) K₂CO₃ / 1) acetone, reflux, 2) reflux

With ammonium acetate; sulfuric acid; hydrogen bromide; potassium carbonate; In ethanol; acetic acid;

Reference yield:

4-methoxyphenyl benzyl ketone (1023-17-2) → [4-(2,5-Diphenyl-oxazol-4-yl)-phenoxy]-acetic acid ethyl ester (84671-91-0)

Guidance literature:

Multi-step reaction with 5 steps

1: 90 percent / AlCl₃ / diethyl ether / 2 h / 0 °C

2: 80 percent / conc. sulphuric acid / ethanol / 8 h / Heating

3: 74 percent / ammonium acetate / acetic acid / 1 h / Heating

4: 48 percent / 47percent HBr / acetic acid / 6 h / Heating

5: 1) K₂CO₃ / 1) acetone, reflux, 2) reflux

With ammonium acetate; aluminium trichloride; sulfuric acid; hydrogen bromide; potassium carbonate; In diethyl ether; ethanol; acetic acid;

upstream raw materials:

4-(2,5-diphenyl-oxazol-4-yl)-phenol

ethyl bromoacetate

sodium benzoate

2-bromo-1-(4-methoxy-phenyl)-2-phenyl-ethanone

Downstream raw materials:

[4-(2,5-Diphenyl-oxazol-4-yl)-phenoxy]-acetic acid