2-(4-bromophenoxy)-N-(2-hydroxyethyl)acetamide

Base Information

• Chemical Name: 2-(4-bromophenoxy)-N-(2-hydroxyethyl)acetamide
• CAS No.: 51837-55-9
• Molecular Formula: C₁₀H₁₂BrNO₃
• Molecular Weight: 274.114
• DSSTox Substance ID: DTXSID20366872
• Wikidata: Q82152323
• ChEMBL ID: CHEMBL1594950
• Mol file: 51837-55-9.mol

Synonyms:2-(4-bromophenoxy)-N-(2-hydroxyethyl)acetamide;51837-55-9;HMS2582P21;Cambridge id 7330941;MLS000680707;CHEMBL1594950;DTXSID20366872;BCA83755;AKOS008930230;SMR000272607;SR-01000258984;SR-01000258984-1

Chemical Property of 2-(4-bromophenoxy)-N-(2-hydroxyethyl)acetamide

Chemical Property:

• XLogP3: 1.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 273.00006
• Heavy Atom Count: 15
• Complexity: 193

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC(=CC=C1OCC(=O)NCCO)Br

Technology Process of 2-(4-bromophenoxy)-N-(2-hydroxyethyl)acetamide

There total 1 articles about 2-(4-bromophenoxy)-N-(2-hydroxyethyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(4-bromophenoxy)acetic acid methyl ester (4841-23-0) + ethanolamine (141-43-5) → (4-bromo-phenoxy)-acetic acid-(2-hydroxy-ethylamide) (51837-55-9)

Guidance literature:

at 100 - 150 ℃;

DOI:10.1021/ja01189a003

Reference yield:

(4-bromo-phenoxy)-acetic acid-(2-hydroxy-ethylamide) (51837-55-9) → 2-(4-bromo-phenoxymethyl)-4,5-dihydro-oxazole (51816-26-3)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂

2: NaOMe / methanol / 1 h / Heating

With thionyl chloride; sodium methylate; In methanol;

Reference yield:

(4-bromo-phenoxy)-acetic acid-(2-hydroxy-ethylamide) (51837-55-9) → 2-(4-bromo-phenoxy)-N-(2-chloro-ethyl)-acetamide (51816-14-9)

Guidance literature:

With thionyl chloride;

upstream raw materials:

(4-bromophenoxy)acetic acid methyl ester

ethanolamine

Downstream raw materials:

2-(4-bromo-phenoxy)-N-(2-chloro-ethyl)-acetamide

2-(4-bromo-phenoxymethyl)-4,5-dihydro-oxazole