(2R)-2-(3-fluorophenyl)-2-hydroxyacetic acid

Base Information

• Chemical Name: (2R)-2-(3-fluorophenyl)-2-hydroxyacetic acid
• CAS No.: 52950-14-8
• Molecular Formula: C₈H₇FO₃
• Molecular Weight: 170.14
• Mol file: 52950-14-8.mol

Synonyms:

Chemical Property of (2R)-2-(3-fluorophenyl)-2-hydroxyacetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R)-2-(3-fluorophenyl)-2-hydroxyacetic acid

There total 25 articles about (2R)-2-(3-fluorophenyl)-2-hydroxyacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

sodium cyanide (773837-37-9) + 3-Fluorobenzaldehyde (456-48-4) → 2-(3-fluorophenyl)-2-hydroxyacetic acid (32222-47-2,52923-24-7,52950-14-8,395-05-1)

Guidance literature:

sodium cyanide; 3-Fluorobenzaldehyde; With benzyltrimethylammonium chloride; In diethyl ether; at 0 ℃; for 0.0833333h;

With hydrogenchloride; water; In diethyl ether; at 20 ℃; for 16h;

Reference yield: 32.0%

2-(3-fluorophenyl)-2-hydroxyacetic acid (32222-47-2,52923-24-7,52950-14-8,395-05-1) → (2R)-2-(3-fluorophenyl)-2-hydroxyacetic acid (395-05-1,52923-24-7,52950-14-8,32222-47-2)

Guidance literature:

With vinyl acetate; In tert-butyl methyl ether; at 26 ℃; for 90h; Enzymatic reaction;

Reference yield:

3-Fluorobenzaldehyde (456-48-4) → 2-(3-fluorophenyl)-2-hydroxyacetic acid (32222-47-2,52923-24-7,52950-14-8,395-05-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 10percent aq. H₂SO₄ / ethanol / 7.9 °C

2: conc. aq. HCl / 19 h / Ambient temperature

With hydrogenchloride; sulfuric acid; In ethanol;

DOI:10.1107/S0108768193010766

upstream raw materials:

(R,S)-2-hydroxy-2-(3-aminophenyl)acetic acid

2-(3-fluorophenyl)-2-((trimethylsilyl)oxy)acetonitrile

chloro-trimethyl-silane

potassium cyanide

Downstream raw materials:

(2R)-2-(3-fluorophenyl)-2-hydroxyacetic acid

C₈H₆ClFO₂

(S)-2-(3-fluorophenyl)-2-hydroxyacetic acid

2-(3-fluorophenyl)-2-oxoacetic acid