1'--L-alanyl>-5'-(ethoxycarbonyl)-7-(aminosulfonyl)-6-chlorospiro-<2H-1,2,4-benzothiadiazine-3(4H),3'-pyrrolidine> S,S-dioxide

Base Information

Chemical Name:1'--L-alanyl>-5'-(ethoxycarbonyl)-7-(aminosulfonyl)-6-chlorospiro-<2H-1,2,4-benzothiadiazine-3(4H),3'-pyrrolidine> S,S-dioxide
CAS No.:126373-61-3
Molecular Formula:C₂₈H₃₆ClN₅O₉S₂
Molecular Weight:686.207
Hs Code.:

1'-<N'-<(1S)-1-(ethoxycarbonyl)-3-phenylpropyl>-L-alanyl>-5'-(ethoxycarbonyl)-7-(aminosulfonyl)-6-chlorospiro-<2H-1,2,4-benzothiadiazine-3(4H),3'-pyrrolidine> S,S-dioxide

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Chemical Property of 1'--L-alanyl>-5'-(ethoxycarbonyl)-7-(aminosulfonyl)-6-chlorospiro-<2H-1,2,4-benzothiadiazine-3(4H),3'-pyrrolidine> S,S-dioxide

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Technology Process of 1'--L-alanyl>-5'-(ethoxycarbonyl)-7-(aminosulfonyl)-6-chlorospiro-<2H-1,2,4-benzothiadiazine-3(4H),3'-pyrrolidine> S,S-dioxide

There total 6 articles about 1'--L-alanyl>-5'-(ethoxycarbonyl)-7-(aminosulfonyl)-6-chlorospiro-<2H-1,2,4-benzothiadiazine-3(4H),3'-pyrrolidine> S,S-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 103632-12-8,126373-56-6,126373-57-7
1'--N'-<(2,2,2-trichloroethoxy)carbonyl>-L-alanyl>-5'-(ethoxycarbonyl)-7-(aminosulfonyl)-6-chlorospiro-<2H-1,2,4-benzothiadiazine-3(4H),3'-pyrrolidine> S,S-dioxide

: 126373-61-3,126373-62-4
1'--L-alanyl>-5'-(ethoxycarbonyl)-7-(aminosulfonyl)-6-chlorospiro-<2H-1,2,4-benzothiadiazine-3(4H),3'-pyrrolidine> S,S-dioxide

Guidance literature:: With acetic acid; zinc; In ethanol; for 22h;
DOI:10.1021/jm00168a013

Reference yield:

: 121-30-2
chloraminophenamide

: 126373-61-3,126373-62-4
1'--L-alanyl>-5'-(ethoxycarbonyl)-7-(aminosulfonyl)-6-chlorospiro-<2H-1,2,4-benzothiadiazine-3(4H),3'-pyrrolidine> S,S-dioxide

Guidance literature:: Multi-step reaction with 2 steps

1: 40 percent / 2 N HCl / ethanol / 1.5 h / 65 °C

2: 90 percent / HOAc, Zn / ethanol / 22 h

With hydrogenchloride; acetic acid; zinc; In ethanol;
DOI:10.1021/jm00168a013

Reference yield:

: 92893-50-0
N-[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]-N-(2,2,2-trichloroethoxycarbonyl)-L-alanine

: 126373-61-3,126373-62-4
1'--L-alanyl>-5'-(ethoxycarbonyl)-7-(aminosulfonyl)-6-chlorospiro-<2H-1,2,4-benzothiadiazine-3(4H),3'-pyrrolidine> S,S-dioxide

Guidance literature:: Multi-step reaction with 5 steps

1: oxalyl chloride, DMF / CH₂Cl₂ / 3.5 h / Ambient temperature

2: Et₃N / CH₂Cl₂ / Ambient temperature

3: 95 percent / pyridinium chlorochromate / CH₂Cl₂ / 72 h / Ambient temperature

4: 40 percent / 2 N HCl / ethanol / 1.5 h / 65 °C

5: 90 percent / HOAc, Zn / ethanol / 22 h

With hydrogenchloride; oxalyl dichloride; acetic acid; triethylamine; N,N-dimethyl-formamide; pyridinium chlorochromate; zinc; In ethanol; dichloromethane;
DOI:10.1021/jm00168a013