1-(4-methylphenyl)-3-(morpholin-4-yl)propan-1-one

Base Information

Chemical Name:1-(4-methylphenyl)-3-(morpholin-4-yl)propan-1-one
CAS No.:5250-04-4
Molecular Formula:C14H19 N O2 . Cl H
Molecular Weight:269.771
Hs Code.:
Mol file:5250-04-4.mol

Synonyms:1-Propanone,1-(4-methylphenyl)-3-(4-morpholinyl)-, hydrochloride (9CI); Propiophenone,4'-methyl-3-morpholino-, hydrochloride (7CI,8CI)

Suppliers and Price of 1-(4-methylphenyl)-3-(morpholin-4-yl)propan-1-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of 1-(4-methylphenyl)-3-(morpholin-4-yl)propan-1-one

Chemical Property:

Vapor Pressure:6.56E-06mmHg at 25°C
Boiling Point:377.8°C at 760 mmHg
Flash Point:182.3°C
Density:1.068g/cm³

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1-(4-methylphenyl)-3-(morpholin-4-yl)propan-1-one

There total 4 articles about 1-(4-methylphenyl)-3-(morpholin-4-yl)propan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 10024-89-2
morpholin hydrochloride

: 122-00-9
para-methylacetophenone

: 5250-04-4
1-morpholino-3-oxo-3-(4-methylphenyl)propane hydrochloride

Guidance literature:: In acetic acid; at 120 ℃; for 2.08333h;
DOI:10.2174/1570180814666161128120612

Reference yield: 28.7%

: 110-91-8,99108-56-2
morpholine

: 5250-02-2
3-(dimethylamino)-4'-methyl propiophenone hydrochloride

: 5250-04-4
1-morpholino-3-oxo-3-(4-methylphenyl)propane hydrochloride

Guidance literature:: morpholine; 3-(dimethylamino)-4'-methyl propiophenone hydrochloride; at 60 ℃; for 0.5h; Inert atmosphere;

With hydrogenchloride; In methanol; diethyl ether; Inert atmosphere;
DOI:10.1016/j.bmcl.2021.127780

Reference yield:

: 122-00-9
para-methylacetophenone

: 5250-04-4
1-morpholino-3-oxo-3-(4-methylphenyl)propane hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: sulfuric acid / acetonitrile / 9 h / Reflux; Inert atmosphere

2.1: 0.5 h / 60 °C / Inert atmosphere

2.2: Inert atmosphere

With sulfuric acid; In acetonitrile;
DOI:10.1016/j.bmcl.2021.127780