Cyclohexanecarboxylic acid, 2-oxo-5-phenyl-, ethyl ester

Base Information

• Chemical Name: Cyclohexanecarboxylic acid, 2-oxo-5-phenyl-, ethyl ester
• CAS No.: 13658-19-0
• Molecular Formula: C15H18O3
• Molecular Weight: 246.306
• Mol file: 13658-19-0.mol

Synonyms:ethyl 4-phenylcyclohexanone-2-carboxylate;2-Oxo-5-phenylcyclohexancarboxylat;ethyl 2-oxo-5-phenylcyclohexanecarboxylate;Cyclohexanecarboxylic acid,2-oxo-5-phenyl-,ethyl ester;

Chemical Property of Cyclohexanecarboxylic acid, 2-oxo-5-phenyl-, ethyl ester

Chemical Property:

• PSA: 43.37000
• LogP: 2.70250

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Cyclohexanecarboxylic acid, 2-oxo-5-phenyl-, ethyl ester

There total 2 articles about Cyclohexanecarboxylic acid, 2-oxo-5-phenyl-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-phenyl-4-cyclohexanone (4894-75-1) + Diethyl carbonate (105-58-8,76619-83-5) → ethyl 2-oxo-5-phenylcyclohexanecarboxylate (13658-19-0)

Guidance literature:

With potassium hydride; sodium hydride; In tetrahydrofuran; at 65 ℃;

DOI:10.1016/j.bmcl.2015.04.068

Reference yield:

→ ethyl 2-oxo-5-phenylcyclohexanecarboxylate (13658-19-0)

Guidance literature:

γ-Phenyl-pimelinsaeure-aethylester, Oxalsaeure-aethylester, Na-aethylat, Aethylenglykol;

Reference yield: 88.0%

chloro-trimethyl-silane (75-77-4) + ethyl 2-oxo-5-phenylcyclohexanecarboxylate (13658-19-0) → 3-[ethoxy(trimethylsilyloxy)methylidene]-5-phenyl-2-trimethylsilyloxycyclohex-1-ene

Guidance literature:

With diisopropylamine; lithium diisopropyl amide; In tetrahydrofuran; hexane; at 0 ℃; for 3h;

DOI:10.1002/1099-0690(200110)2001:19<3657::AID-EJOC3657>3.0.CO;2-5

upstream raw materials:

1-phenyl-4-cyclohexanone

Diethyl carbonate

Downstream raw materials:

ethyl 2-mercapto-5-phenyl-1-cyclohexene-1-carboxylate