9-(2-deoxy-5-O-phosphonopentofuranosyl)-2-{[(1R,2S,3R,4S)-2,3,4-trihydroxy-7-methyl-1,2,3,4-tetrahydrotetraphen-1-yl]amino}-3,9-dihydro-6H-purin-6-one

Base Information

• Chemical Name: 9-(2-deoxy-5-O-phosphonopentofuranosyl)-2-{[(1R,2S,3R,4S)-2,3,4-trihydroxy-7-methyl-1,2,3,4-tetrahydrotetraphen-1-yl]amino}-3,9-dihydro-6H-purin-6-one
• CAS No.: 133551-46-9
• Molecular Formula: C₂₉H₂₉N₅O₇
• Molecular Weight: 559.579
• Mol file: 133551-46-9.mol

Synonyms:

Chemical Property of 9-(2-deoxy-5-O-phosphonopentofuranosyl)-2-{[(1R,2S,3R,4S)-2,3,4-trihydroxy-7-methyl-1,2,3,4-tetrahydrotetraphen-1-yl]amino}-3,9-dihydro-6H-purin-6-one

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 9-(2-deoxy-5-O-phosphonopentofuranosyl)-2-{[(1R,2S,3R,4S)-2,3,4-trihydroxy-7-methyl-1,2,3,4-tetrahydrotetraphen-1-yl]amino}-3,9-dihydro-6H-purin-6-one

There total 4 articles about 9-(2-deoxy-5-O-phosphonopentofuranosyl)-2-{[(1R,2S,3R,4S)-2,3,4-trihydroxy-7-methyl-1,2,3,4-tetrahydrotetraphen-1-yl]amino}-3,9-dihydro-6H-purin-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(+/-)-trans-3,4-Dihydroxy-anti-1,2-epoxy-7-methyl-1,2,3,4-tetrahydrobenzanthracene (133645-02-0,63057-64-7,64625-66-7) + 2'-deoxyguanosine 5'-monophosphate (902-04-5) → Phosphoric acid mono-{(2R,3S,5R)-3-hydroxy-5-[6-oxo-2-(2,3,4-trihydroxy-7-methyl-1,2,3,4-tetrahydro-benzo[a]anthracen-1-ylamino)-1,6-dihydro-purin-9-yl]-tetrahydro-furan-2-ylmethyl} ester (133551-46-9,133645-03-1,133645-07-5,133646-13-6)

Guidance literature:

With tris-HCl-buffer; In acetone; at 37 ℃;

DOI:10.1021/jo00013a020

Reference yield:

2'-deoxyguanosine 5'-monophosphate (902-04-5) → 9-((2R,4S,5R)-4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2-((1R,2S,3R,4S)-2,3,4-trihydroxy-7-methyl-1,2,3,4-tetrahydro-benzo[a]anthracen-1-ylamino)-1,9-dihydro-purin-6-one (133551-46-9)

Guidance literature:

Multi-step reaction with 2 steps

1: Tris-HCl-buffer / acetone / 37 °C

2: alkaline phosphatase

With tris-HCl-buffer; In acetone;

DOI:10.1021/jo00013a020

Reference yield:

(+/-)-trans-3,4-Dihydroxy-anti-1,2-epoxy-7-methyl-1,2,3,4-tetrahydrobenzanthracene (133645-02-0,63057-64-7,64625-66-7) → 9-((2R,4S,5R)-4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2-((1S,2R,3S,4R)-2,3,4-trihydroxy-7-methyl-1,2,3,4-tetrahydro-benzo[a]anthracen-1-ylamino)-1,9-dihydro-purin-6-one (133646-13-6) + 9-((2R,4S,5R)-4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2-((1R,2S,3R,4S)-2,3,4-trihydroxy-7-methyl-1,2,3,4-tetrahydro-benzo[a]anthracen-1-ylamino)-1,9-dihydro-purin-6-one (133551-46-9) + 9-((2R,4S,5R)-4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2-((1R,2R,3S,4R)-2,3,4-trihydroxy-7-methyl-1,2,3,4-tetrahydro-benzo[a]anthracen-1-ylamino)-1,9-dihydro-purin-6-one (133645-07-5)

Guidance literature:

With tris-HCl-buffer; Multistep reaction; 1.) acetone, 37 deg C, 2.) snake venom phosphodiesterase, alkal. phosphomonoesterase;

DOI:10.1021/jo00013a020

upstream raw materials:

(+/-)-trans-3,4-Dihydroxy-anti-1,2-epoxy-7-methyl-1,2,3,4-tetrahydrobenzanthracene

2'-deoxyguanosine 5'-monophosphate

Phosphoric acid mono-{(2R,3S,5R)-3-hydroxy-5-[6-oxo-2-(2,3,4-trihydroxy-7-methyl-1,2,3,4-tetrahydro-benzo[a]anthracen-1-ylamino)-1,6-dihydro-purin-9-yl]-tetrahydro-furan-2-ylmethyl} ester

Downstream raw materials:

9-((2R,4S,5R)-4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2-((1S,2S,3R,4S)-2,3,4-trihydroxy-7-methyl-1,2,3,4-tetrahydro-benzo[a]anthracen-1-ylamino)-1,9-dihydro-purin-6-one

9-((2R,4S,5R)-4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2-((1S,2R,3S,4R)-2,3,4-trihydroxy-7-methyl-1,2,3,4-tetrahydro-benzo[a]anthracen-1-ylamino)-1,9-dihydro-purin-6-one

9-((2R,4S,5R)-4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2-((1R,2R,3S,4R)-2,3,4-trihydroxy-7-methyl-1,2,3,4-tetrahydro-benzo[a]anthracen-1-ylamino)-1,9-dihydro-purin-6-one