2,2-Dimethyl-propionic acid (2R,4S,5R)-4,6-bis-benzyloxy-5-(2,2-dimethyl-propionyloxy)-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-hexyl ester

Base Information

Chemical Name:2,2-Dimethyl-propionic acid (2R,4S,5R)-4,6-bis-benzyloxy-5-(2,2-dimethyl-propionyloxy)-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-hexyl ester
CAS No.:183959-16-2
Molecular Formula:C₃₄H₄₄N₂O₈
Molecular Weight:608.732
Hs Code.:

2,2-Dimethyl-propionic acid (2R,4S,5R)-4,6-bis-benzyloxy-5-(2,2-dimethyl-propionyloxy)-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-hexyl ester

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Chemical Property of 2,2-Dimethyl-propionic acid (2R,4S,5R)-4,6-bis-benzyloxy-5-(2,2-dimethyl-propionyloxy)-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-hexyl ester

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Technology Process of 2,2-Dimethyl-propionic acid (2R,4S,5R)-4,6-bis-benzyloxy-5-(2,2-dimethyl-propionyloxy)-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-hexyl ester

There total 6 articles about 2,2-Dimethyl-propionic acid (2R,4S,5R)-4,6-bis-benzyloxy-5-(2,2-dimethyl-propionyloxy)-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-hexyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 183959-15-1
2,2-Dimethyl-propionic acid (2R,4S,5R)-2-(3-benzoyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4,6-bis-benzyloxy-5-(2,2-dimethyl-propionyloxy)-hexyl ester

: 183959-16-2
2,2-Dimethyl-propionic acid (2R,4S,5R)-4,6-bis-benzyloxy-5-(2,2-dimethyl-propionyloxy)-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-hexyl ester

Guidance literature:: With ammonium hydroxide; In methanol; for 8h; Yield given; Ambient temperature;
DOI:10.1016/0040-4020(96)00818-6

Reference yield:

: 3282-30-2
pivaloyl chloride

: 183959-16-2
2,2-Dimethyl-propionic acid (2R,4S,5R)-4,6-bis-benzyloxy-5-(2,2-dimethyl-propionyloxy)-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-hexyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 93 percent / pyridine / Ambient temperature

2: 63 percent / AD-mix-α, water / 2-methyl-propan-2-ol / 1.) ) deg C, 6 h, 2.) RT, overnight

3: 93 percent / pyridine / 2 h / 0 °C

4: Ph₃P, DEAD / dioxane / Ambient temperature

5: aq. NH₄OH / methanol / 8 h / Ambient temperature

With pyridine; ammonium hydroxide; AD-mix-α; water; triphenylphosphine; diethylazodicarboxylate; In 1,4-dioxane; methanol; tert-butyl alcohol;
DOI:10.1016/0040-4020(96)00818-6

Reference yield:

: 116444-15-6
(2R,3S)-1,3-O-dibenzyl-2-hydroxy-5-hexene

: 183959-16-2
2,2-Dimethyl-propionic acid (2R,4S,5R)-4,6-bis-benzyloxy-5-(2,2-dimethyl-propionyloxy)-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-hexyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 93 percent / pyridine / Ambient temperature

2: 63 percent / AD-mix-α, water / 2-methyl-propan-2-ol / 1.) ) deg C, 6 h, 2.) RT, overnight

3: 93 percent / pyridine / 2 h / 0 °C

4: Ph₃P, DEAD / dioxane / Ambient temperature

5: aq. NH₄OH / methanol / 8 h / Ambient temperature

With pyridine; ammonium hydroxide; AD-mix-α; water; triphenylphosphine; diethylazodicarboxylate; In 1,4-dioxane; methanol; tert-butyl alcohol;
DOI:10.1016/0040-4020(96)00818-6