Methyl 4-(2-chloroacetyl)-5-methyl-1H-pyrrole-2-carboxylate

Base Information

Chemical Name:Methyl 4-(2-chloroacetyl)-5-methyl-1H-pyrrole-2-carboxylate
CAS No.:203208-33-7
Molecular Formula:C₉H₁₀ClNO₃
Molecular Weight:215.636
Hs Code.:
European Community (EC) Number:869-679-6

Synonyms:Methyl 4-(2-chloroacetyl)-5-methyl-1H-pyrrole-2-carboxylate;203208-33-7;EN300-342451;Z1508674792;Methyl4-(2-chloroacetyl)-5-methyl-1H-pyrrole-2-carboxylate

Suppliers and Price of Methyl 4-(2-chloroacetyl)-5-methyl-1H-pyrrole-2-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

AK Scientific
Methyl4-(2-chloroacetyl)-5-methyl-1H-pyrrole-2-carboxylate
2.5g
$ 1404.00

AK Scientific
Methyl4-(2-chloroacetyl)-5-methyl-1H-pyrrole-2-carboxylate
250mg
$ 372.00

Total 2 raw suppliers

Chemical Property of Methyl 4-(2-chloroacetyl)-5-methyl-1H-pyrrole-2-carboxylate

Chemical Property:

XLogP3:1.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:215.0349209
Heavy Atom Count:14
Complexity:244

Purity/Quality:

95% ^*data from raw suppliers

Methyl4-(2-chloroacetyl)-5-methyl-1H-pyrrole-2-carboxylate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=C(C=C(N1)C(=O)OC)C(=O)CCl

Technology Process of Methyl 4-(2-chloroacetyl)-5-methyl-1H-pyrrole-2-carboxylate

There total 1 articles about Methyl 4-(2-chloroacetyl)-5-methyl-1H-pyrrole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1194-97-4
methyl 5-methyl-1H-pyrrole-2-carboxylate

: 79-04-9
chloroacetyl chloride

: 203208-33-7
4-(2-Chloro-acetyl)-5-methyl-1H-pyrrole-2-carboxylic acid methyl ester

Guidance literature:: With aluminium trichloride; In dichloromethane; for 2h; Ambient temperature;
DOI:10.1021/jm970416w

Reference yield:

: 203208-33-7
4-(2-Chloro-acetyl)-5-methyl-1H-pyrrole-2-carboxylic acid methyl ester

: 203207-24-3
4-Benzyloxy-5-methyl-1H-pyrrole-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 64 percent / m-chloroperbenzoic acid, Na₂HPO₄ / CH₂Cl₂ / 5 h / Ambient temperature

2: 80 percent / aq. K₂CO₃ / methanol / 0.25 h / Ambient temperature

3: 50 percent / NaH / dimethylformamide / a) -20 deg C, 15 min, b) RT, 1 h

With disodium hydrogenphosphate; sodium hydride; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm970416w

Reference yield:

: 203208-33-7
4-(2-Chloro-acetyl)-5-methyl-1H-pyrrole-2-carboxylic acid methyl ester

: 203207-42-5
4-Benzyloxy-3-formyl-5-methyl-1H-pyrrole-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 64 percent / m-chloroperbenzoic acid, Na₂HPO₄ / CH₂Cl₂ / 5 h / Ambient temperature

2: 80 percent / aq. K₂CO₃ / methanol / 0.25 h / Ambient temperature

3: 50 percent / NaH / dimethylformamide / a) -20 deg C, 15 min, b) RT, 1 h

4: 78 percent / POCl₃ / 1,2-dichloro-ethane / Heating

With disodium hydrogenphosphate; sodium hydride; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; trichlorophosphate; In methanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1021/jm970416w