(6R)-4ξ-methoxy-3-methyl-5t,8-dioxo-7t-(2-phenoxy-acetylamino)-4ξ-(3-phenyl-ureidomethyl)-(6rH)-5λ⁴-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-nitro-benzyl ester

Base Information

• Chemical Name: (6R)-4ξ-methoxy-3-methyl-5t,8-dioxo-7t-(2-phenoxy-acetylamino)-4ξ-(3-phenyl-ureidomethyl)-(6rH)-5λ⁴-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-nitro-benzyl ester
• CAS No.: 66095-11-2
• Molecular Formula: C₃₂H₃₁N₅O₁₀S
• Molecular Weight: 677.692

Synonyms:

Chemical Property of (6R)-4ξ-methoxy-3-methyl-5t,8-dioxo-7t-(2-phenoxy-acetylamino)-4ξ-(3-phenyl-ureidomethyl)-(6rH)-5λ⁴-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-nitro-benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (6R)-4ξ-methoxy-3-methyl-5t,8-dioxo-7t-(2-phenoxy-acetylamino)-4ξ-(3-phenyl-ureidomethyl)-(6rH)-5λ⁴-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-nitro-benzyl ester

There total 2 articles about (6R)-4ξ-methoxy-3-methyl-5t,8-dioxo-7t-(2-phenoxy-acetylamino)-4ξ-(3-phenyl-ureidomethyl)-(6rH)-5λ⁴-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-nitro-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(5R)-3-methyl-4-methylene-5t,8-dioxo-7t-(2-phenoxy-acetylamino)-(6rH)-5λ4-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-nitro-benzyl ester (66138-37-2) → (6R)-4ξ-methoxy-3-methyl-5t,8-dioxo-7t-(2-phenoxy-acetylamino)-4ξ-(3-phenyl-ureidomethyl)-(6rH)-5λ4-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-nitro-benzyl ester (66095-11-2)

Guidance literature:

Multi-step reaction with 2 steps

1: Ph₂SNH / dimethylformamide / 0 °C

2: (i) , (ii) /BRN= 1098229/

With Ph₂SnH; In N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(01)83306-2

Reference yield:

methanol (67-56-1) + phenyl isocyanate (103-71-9) + (4'R)-3'-methyl-5't,8'-dioxo-7't-(2-phenoxy-acetylamino)-(4'rN,6'cH)-5'λ4-spiro[aziridine-2,4'-(5-thia-1-aza-bicyclo[4.2.0]oct-2-ene)]-2'-carboxylic acid 4-nitro-benzyl ester (66094-92-6) → (6R)-4ξ-methoxy-3-methyl-5t,8-dioxo-7t-(2-phenoxy-acetylamino)-4ξ-(3-phenyl-ureidomethyl)-(6rH)-5λ4-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-nitro-benzyl ester (66095-11-2)

Guidance literature:

Multistep reaction; (i) , (ii) /BRN= 1098229/;

DOI:10.1016/S0040-4039(01)83306-2

upstream raw materials:

methanol

phenyl isocyanate

(4'R)-3'-methyl-5't,8'-dioxo-7't-(2-phenoxy-acetylamino)-(4'rN,6'cH)-5'λ⁴-spiro[aziridine-2,4'-(5-thia-1-aza-bicyclo[4.2.0]oct-2-ene)]-2'-carboxylic acid 4-nitro-benzyl ester

(5R)-3-methyl-4-methylene-5t,8-dioxo-7t-(2-phenoxy-acetylamino)-(6rH)-5λ⁴-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-nitro-benzyl ester

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