2-({2-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-tetrahydro-furan-2-carbonyl}-amino)-3-(2',6'-dimethoxy-biphenyl-4-yl)-propionic acid tert-butyl ester

Base Information

Chemical Name:2-({2-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-tetrahydro-furan-2-carbonyl}-amino)-3-(2',6'-dimethoxy-biphenyl-4-yl)-propionic acid tert-butyl ester
CAS No.:327618-60-0
Molecular Formula:C₃₄H₅₁NO₇Si
Molecular Weight:613.867
Hs Code.:

2-({2-[2-(<i>tert</i>-butyl-dimethyl-silanyloxy)-ethyl]-tetrahydro-furan-2-carbonyl}-amino)-3-(2',6'-dimethoxy-biphenyl-4-yl)-propionic acid <i>tert</i>-butyl ester

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Chemical Property of 2-({2-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-tetrahydro-furan-2-carbonyl}-amino)-3-(2',6'-dimethoxy-biphenyl-4-yl)-propionic acid tert-butyl ester

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Technology Process of 2-({2-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-tetrahydro-furan-2-carbonyl}-amino)-3-(2',6'-dimethoxy-biphenyl-4-yl)-propionic acid tert-butyl ester

There total 4 articles about 2-({2-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-tetrahydro-furan-2-carbonyl}-amino)-3-(2',6'-dimethoxy-biphenyl-4-yl)-propionic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 101166-65-8
2-tert-butyldimethylsilyloxyethyl iodide

: 327618-60-0
2-({2-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-tetrahydro-furan-2-carbonyl}-amino)-3-(2',6'-dimethoxy-biphenyl-4-yl)-propionic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: LDA / hexamethylphosphoric acid triamide

2: H₂; Et₃N / Pd/C / methanol

3: PyBOP; DIPEA / CH₂Cl₂

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide; palladium on activated charcoal; In methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane;
DOI:10.1016/S0960-894X(02)00211-1

Reference yield:

: 78277-21-1
benzyl (+/-)-tetrahydrofuran-2-carboxylate

: 327618-60-0
2-({2-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-tetrahydro-furan-2-carbonyl}-amino)-3-(2',6'-dimethoxy-biphenyl-4-yl)-propionic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: LDA / hexamethylphosphoric acid triamide

2: H₂; Et₃N / Pd/C / methanol

3: PyBOP; DIPEA / CH₂Cl₂

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide; palladium on activated charcoal; In methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane;
DOI:10.1016/S0960-894X(02)00211-1

Reference yield:

: 327618-58-6
2-(2-tert-butyl-dimethylsilyl-oxyethyl)-2-tetrahydrofuroic acid, benzyl ester

: 327618-60-0
2-({2-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-tetrahydro-furan-2-carbonyl}-amino)-3-(2',6'-dimethoxy-biphenyl-4-yl)-propionic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: H₂; Et₃N / Pd/C / methanol

2: PyBOP; DIPEA / CH₂Cl₂

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1016/S0960-894X(02)00211-1