101166-65-8

Basic information

• Product Name: TERT-BUTYL-(2-IODO-ETHOXY)-DIMETHYL-SILANE
• Synonyms: (1,1-DIMETHYLETHYL)(2-IODOETHOXY)DIMETHYL-SILANE;1-(tert-Butyldimethylsilyloxy)-2-iodoethane;1-Iodo-2-(tert-butyldimethylsilyloxy)ethane;2-Iodo-1-(1,1,2,2-tetramethyl-1-silapropoxy)ethane;Silane,(1,1-dimethylethyl)(2-iodoethoxy)dimethyl-;tert-Butyl(2-iodoethoxy);TERT-BUTYL-(2-IODO-ETHOXY)-DIMETHYL-SILANE
• CAS NO: 101166-65-8
• Molecular Formula: C₈H₁₉IOSi
• Molecular Weight: 286.23
• Mol File: 101166-65-8.mol
• Article Data: 25

Chemical Properties

• Boiling Point: 210℃
• Flash Point: 81℃
• Appearance: /
• Density: 1.291
• Vapor Pressure: 0.288mmHg at 25°C
• Refractive Index: 1.476
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: TERT-BUTYL-(2-IODO-ETHOXY)-DIMETHYL-SILANE(CAS DataBase Reference)
• NIST Chemistry Reference: TERT-BUTYL-(2-IODO-ETHOXY)-DIMETHYL-SILANE(101166-65-8)
• EPA Substance Registry System: TERT-BUTYL-(2-IODO-ETHOXY)-DIMETHYL-SILANE(101166-65-8)

Safety Data

• Hazardous Substances Data: 101166-65-8(Hazardous Substances Data)

Usage

General Description

TERT-BUTYL-(2-IODO-ETHOXY)-DIMETHYL-SILANE is a chemical compound that contains a tert-butyl group, two dimethyl groups, an iodo-ethoxy group, and a silicon atom. It is commonly used as a reagent in the synthesis of organic compounds, particularly in the field of silicon-based chemistry. TERT-BUTYL-(2-IODO-ETHOXY)-DIMETHYL-SILANE has the potential to be utilized in the development of new materials, such as polymers and coatings. Its specific chemical properties make it valuable in a variety of applications, including in the pharmaceutical and electronics industries. Additionally, TERT-BUTYL-(2-IODO-ETHOXY)-DIMETHYL-SILANE may be used as a building block for the creation of more complex molecules with diverse functionalities.

InChI:InChI=1/C8H19IOSi/c1-8(2,3)11(4,5)10-7-6-9/h6-7H2,1-5H3

Upstream product

• 89031-81-2 tert-butyl (2-chloroethoxy)dimethyl silane 
• 75-03-6 ethyl iodide 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 288-32-4 1H-imidazole 
• 624-76-0 Iodoethanol 
• 102229-10-7 2-(tert-butyldimethylsilyloxy)ethanol 
• 590409-26-0 4-(2-(2-t-butyldimethylsilyloxyethylthio)ethyl)-5,6,7,8-tetrahydrophthalazin-1(2H)-one 
• 86864-60-0 2-(tert-butyldimethylsilyloxy)ethyl bromide 
• 75-21-8 oxirane 

Downstream Products

• 192197-13-0 N-(1-(4-tert-Butylphenyl)-2-propyl)-2-amino-4-(3-tert-butyldimethylsilyloxypropyl)-6-methylpyrimidine 
• 1208358-36-4 C₁₈H₂₆O₂Si 

Relevant articles and documents

A concise synthesis of the pentacyclic framework of cortistatins

(Chemical Equation Presented) An efficient synthesis of the pentacyclic framework of cortistatins has been developed. The key strategy comprises assembly of the A- and the CD-ring fragments by Knoevenagel reaction, facile formation of the pyran ring via e

Cyclic ethers as educts for the synthesis of lepidoptra pheromones

ω-Iodo(trialkylsiloxy)alkanes 2 prepared by ring opening of cyclic ethers with iodotrimethylsilane, are useful starting materials for the synthesis of pheromone components. Reaction with triphenylphosphine to give the corresponding Wittig reagent and subsequent coupling with lithium (Z)-dihex-1-enylcuprate gives (Z)-alken-1-ols 5 and 7, after deprotection, in good yields. The direct coupling of 2 with alkynes failed because of competition reactions, however, the more stable ω-iodo-1-(tert-butyldimethylsiloxy)alkanes were able to undergo C,C-coupling with alkynes. The thus formed 1-(tert-butyldimethylsiloxy)-5-decyne (13c) was hydrogenated and deprotected to give (E)-5-decen-1-ol (15c).

COMPOUNDS AS INHIBITORS OF MACROPHAGE MIGRATION INHIBITORY FACTOR

The present invention provides compounds of Formula (I) shown above and their pharmaceutically acceptable salt, solvates, isomers, or prodrugs, as well as pharmaceutical compositions containing these compounds. Also provided by the invention is a method for treating a disorder mediated by macrophage migration inhibitory factor in a subject, comprising administering to the subject in need thereof a compound or a pharmaceutical composition of this invention.

Evolution of a Polyene Cyclization Cascade for the Total Synthesis of (?)-Cyclosmenospongine

We report a full account on the development of a unique cationic polyene cyclization for the total synthesis of the tetracyclic meroterpenoid (?)-cyclosmenospongine. A highly convergent three-component coupling strategy enabled rapid access to individual cyclization precursors that were tested for their reactivity. The successful transformation generates three rings and sets four consecutive stereocenters in a single operation proceeding in a highly efficient manner to give exclusively the trans-decalin framework. In addition, we found that the enol ether geometry and the relative configuration of C3 and C8 are crucial for the success of the polyene cyclization.