(3R-trans)-5-<(dicyclohexylphosphinyl)methyl>-1-(methylsulfonyl)-3-pyrrolidinol metyhanesulfonate

Base Information

Chemical Name:(3R-trans)-5-<(dicyclohexylphosphinyl)methyl>-1-(methylsulfonyl)-3-pyrrolidinol metyhanesulfonate
CAS No.:110450-61-8
Molecular Formula:C₁₉H₃₆NO₆PS₂
Molecular Weight:469.604
Hs Code.:

Synonyms:

Suppliers and Price of (3R-trans)-5-<(dicyclohexylphosphinyl)methyl>-1-(methylsulfonyl)-3-pyrrolidinol metyhanesulfonate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (3R-trans)-5-<(dicyclohexylphosphinyl)methyl>-1-(methylsulfonyl)-3-pyrrolidinol metyhanesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (3R-trans)-5-<(dicyclohexylphosphinyl)methyl>-1-(methylsulfonyl)-3-pyrrolidinol metyhanesulfonate

There total 11 articles about (3R-trans)-5-<(dicyclohexylphosphinyl)methyl>-1-(methylsulfonyl)-3-pyrrolidinol metyhanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 124-63-0
methanesulfonyl chloride

: 110450-60-7
(3R-trans)-5-<(dicyclohexylphosphinyl)methyl>-1-(methylsulfonyl)-3-pyrrolidinol

: 110450-61-8
(3R-trans)-5-<(dicyclohexylphosphinyl)methyl>-1-(methylsulfonyl)-3-pyrrolidinol metyhanesulfonate

Guidance literature:: DOI:10.1246/cl.1986.2061

Reference yield:

: 33996-30-4
trans-4-hydroxy-L-proline ethyl ester hydrochloride

: 110450-61-8
(3R-trans)-5-<(dicyclohexylphosphinyl)methyl>-1-(methylsulfonyl)-3-pyrrolidinol metyhanesulfonate

Guidance literature:: Multi-step reaction with 9 steps

1: 79 percent / anh. pyridine / a) 0 deg C, 6 h, b) RT, 15 h

2: 87 percent / LiAlH₄ / tetrahydrofuran / a) 0 deg C, 3 h, b) RT, 3 h

3: 100 percent / pyridine / a) -25 deg C, 15 h, b) 0 deg C, 4 h, c)RT, 1 h

4: 100 percent / pTsOH monohydrate / CH₂Cl₂ / 3 h / Ambient temperature

5: 67 percent / tetrahydrofuran; dioxane / a) 0 deg C, 6 h, b) RT, 13 h

6: 10percent aq. H₂O₂ / methanol / 1 h / Ambient temperature

7: pTsOH monohydrrate / methanol; H₂O / 1 h / Heating

8: 96 percent / H₂, 5percent Rh on Al₂O₃ powder / methanol / 48 h / 150 °C / 114000 Torr

9: 88 percent / pyridine

With pyridine; lithium aluminium tetrahydride; rhodium on alumina; hydrogen; dihydrogen peroxide; toluene-4-sulfonic acid; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water;
DOI:10.1248/cpb.42.481

Reference yield:

: 110450-59-4
<2S-trans>-2-<(diphenylphosphino)methyl>-1-(methylsulfonyl)-4-<(tetrahydro-2H-pyran-2-yl)oxy>pyrrolidine

: 110450-61-8
(3R-trans)-5-<(dicyclohexylphosphinyl)methyl>-1-(methylsulfonyl)-3-pyrrolidinol metyhanesulfonate

Guidance literature:: Multi-step reaction with 4 steps

1: 10percent aq. H₂O₂ / methanol / 1 h / Ambient temperature

2: pTsOH monohydrrate / methanol; H₂O / 1 h / Heating

3: 96 percent / H₂, 5percent Rh on Al₂O₃ powder / methanol / 48 h / 150 °C / 114000 Torr

4: 88 percent / pyridine

With pyridine; rhodium on alumina; hydrogen; dihydrogen peroxide; toluene-4-sulfonic acid; In methanol; water;
DOI:10.1248/cpb.42.481