N-[4-[(2,4-Dioxo-5-thiazolidinyl)methyl]phenyl]propanamide

Base Information

Chemical Name:N-[4-[(2,4-Dioxo-5-thiazolidinyl)methyl]phenyl]propanamide
CAS No.:85002-38-6
Molecular Formula:C₁₃H₁₄N₂O₃S
Molecular Weight:278.332
Hs Code.:
DSSTox Substance ID:DTXSID601191125

Synonyms:DTXSID601191125;N-[4-[(2,4-Dioxo-5-thiazolidinyl)methyl]phenyl]propanamide;85002-38-6

Suppliers and Price of N-[4-[(2,4-Dioxo-5-thiazolidinyl)methyl]phenyl]propanamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[4-[(2,4-Dioxo-5-thiazolidinyl)methyl]phenyl]propanamide

Chemical Property:

XLogP3:1.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:278.07251349
Heavy Atom Count:19
Complexity:378

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCC(=O)NC1=CC=C(C=C1)CC2C(=O)NC(=O)S2

Technology Process of N-[4-[(2,4-Dioxo-5-thiazolidinyl)methyl]phenyl]propanamide

There total 4 articles about N-[4-[(2,4-Dioxo-5-thiazolidinyl)methyl]phenyl]propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.8%

: 79-03-8
propionyl chloride

: 85002-36-4
5-(4-amino-benzyl)-thiazolidin-2,4-dione

: 85002-38-6
5-(4-propionylaminobenzyl)thiazolidine-2,4-dione

Guidance literature:: DOI:10.1248/cpb.30.3580

Reference yield:

: 57460-34-1
ethyl 2-chloro-3-(4-nitrophenyl)propionate

: 85002-38-6
5-(4-propionylaminobenzyl)thiazolidine-2,4-dione

Guidance literature:: Multi-step reaction with 3 steps

1: 2.) 2N HCl / 1.) sulfolane, 120 deg C, 5 h; 2.) sulfolane, 100 deg C, 15 h

2: 88.6 percent / hydrogen / 10percent Pd-C / methanol; ethyl acetate / 760 Torr / Ambient temperature

3: 55.8 percent

With hydrogenchloride; hydrogen; palladium on activated charcoal; In methanol; ethyl acetate;
DOI:10.1248/cpb.30.3580

Reference yield:

: 100-01-6,104810-17-5
4-nitro-aniline

: 85002-38-6
5-(4-propionylaminobenzyl)thiazolidine-2,4-dione

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) NaNO₂, conc. HCl, 2.) Cu₂O / 1.) acetone, water, 5 deg C, 30 min, 2.) acetone, water, 10 deg C

2: 2.) 2N HCl / 1.) sulfolane, 120 deg C, 5 h; 2.) sulfolane, 100 deg C, 15 h

3: 88.6 percent / hydrogen / 10percent Pd-C / methanol; ethyl acetate / 760 Torr / Ambient temperature

4: 55.8 percent

With copper(I) oxide; hydrogenchloride; hydrogen; sodium nitrite; palladium on activated charcoal; In methanol; ethyl acetate;
DOI:10.1248/cpb.30.3580