(4-fluorophenyl)(3-pyridinyl)methanone O-[2-(dimethylamino)ethyl]oxime

Base Information

• Chemical Name: (4-fluorophenyl)(3-pyridinyl)methanone O-[2-(dimethylamino)ethyl]oxime
• CAS No.: 112702-86-0
• Molecular Formula: C₁₆H₁₈FN₃O
• Molecular Weight: 287.337
• Mol file: 112702-86-0.mol

Synonyms:

Chemical Property of (4-fluorophenyl)(3-pyridinyl)methanone O-[2-(dimethylamino)ethyl]oxime

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4-fluorophenyl)(3-pyridinyl)methanone O-[2-(dimethylamino)ethyl]oxime

There total 2 articles about (4-fluorophenyl)(3-pyridinyl)methanone O-[2-(dimethylamino)ethyl]oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-hydroxy-1-(4-fluorophenyl)-1-(3-pyridinyl)methanimine (328110-68-5) + 2-(dimethylamino)ethyl chloride (107-99-3) → (4-Fluoro-phenyl)-pyridin-3-yl-methanone O-(2-dimethylamino-ethyl)-oxime (295796-20-2,112702-86-0)

Guidance literature:

With sodium hydride; Yield given. Multistep reaction; 1.) DMF, 0.5 h, 2.) 1.5 h; overnight;

DOI:10.1007/BF01145552

Reference yield:

(4-fluorophenyl)(3-pyridinyl)methanone (52779-56-3) → (4-Fluoro-phenyl)-pyridin-3-yl-methanone O-(2-dimethylamino-ethyl)-oxime (295796-20-2,112702-86-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 94 percent / NH₂OH*HCl, NaOH / aq. ethanol / 3 h / Heating

2: 1.) 70percent NaH / 1.) DMF, 0.5 h, 2.) 1.5 h; overnight

With sodium hydroxide; hydroxylamine hydrochloride; sodium hydride; In ethanol;

DOI:10.1007/BF01145552

Reference yield:

oxalic acid (144-62-7,97993-78-7) + (4-Fluoro-phenyl)-pyridin-3-yl-methanone O-(2-dimethylamino-ethyl)-oxime (295796-20-2,112702-86-0) → C16H18FN3O*C2H2O4

Guidance literature:

In ethanol;

DOI:10.1007/s11094-018-1763-z

upstream raw materials:

N-hydroxy-1-(4-fluorophenyl)-1-(3-pyridinyl)methanimine

2-(dimethylamino)ethyl chloride

(4-fluorophenyl)(3-pyridinyl)methanone

Refernces

• 1、 Glozman, O. M.,Zhmurenko, L. A.,Meshcheryakova, L. M.,Borisova, L. N.,Lezina, V. P.,et al.. "SYNTHESIS AND PHARMACOLOGICAL ACTIVITY OF O-AMINOALKYL DERIVATIVES OF OXIMES OF PYRIDYLPHENYLMETHANONES". . p. 624 - 629. Retrieved 2007/10/02.