52779-56-3

Usage

InChI:InChI=1/C12H8FNO/c13-11-5-3-9(4-6-11)12(15)10-2-1-7-14-8-10/h1-8H

Upstream product

• 10400-19-8 3-pyridinecarbonyl chloride 
• 462-06-6 fluorobenzene 
• 20260-53-1 pyridine-3-carbonyl chloride hydrochloride 

Downstream Products

• 77744-09-3 1-(4-Fluorophenyl)-1-(3-pyridyl)-2-propen-1-ol 
• 93943-83-0 (E)-7-(4-Fluoro-phenyl)-7-pyridin-3-yl-hept-6-enoic acid 
• 52779-62-1 diethyl 2-methyl-2-[p-(pyridin-3-ylcarbonyl)phenyl]malonate 
• 1604834-18-5 C₂₂H₁₉FN₂O 
• 118412-66-1 3-(4-fluorobenzoyl)piperidin-1-ium chloride 
• 52779-69-8 ethyl p-(pyridin-3-ylcarbonyl)hydratropate 
• 52779-70-1 p-(pyridin-3-ylcarbonyl)hydratropic acid hydrochloride 
• 1599530-69-4 (3-(4-(1H-pyrazol-1-yl)benzyl)-4-chloro-2-methoxyquinolin-6-yl)(4-fluorophenyl)(pyridin-3-yl)methanol 
• 77744-16-2 Acetic acid 1-(4-fluoro-phenyl)-1-pyridin-3-yl-allyl ester 
• 300812-81-1 (4-Fluoro-phenyl)-pyridin-3-yl-methanone O-(2-diethylamino-ethyl)-oxime 
• 295796-20-2 (4-Fluoro-phenyl)-pyridin-3-yl-methanone O-(2-dimethylamino-ethyl)-oxime 
• 82465-64-3 5-(4-Fluorbenzoyl)-2-pyridincarboxamid 

Relevant academic research and scientific papers

Diarylmethylidenefuran derivatives, processes for their preparation and their uses in therapeutics

The present invention relates to derivatives of the formula the process for their preparation, and to their uses in therapeutics, especially as drugs with anti-inflammatory, analgesic and chemopreventive properties.

Diarylmethylidenefuran derivatives and their uses in therapeutics

The present invention relates to the derivatives of the formula STR1 and to their use in therapeutics, especially as drugs with anti-inflammatory and analgesic properties.

A New Simple Synthesis of Fusaric Acid and Other 5-Alkyl-2-pyridinecarboxylic Acids

Carboxamido groups are introduced into the 6-position of 3-acylpyridines with high regioselectivity via Minisci reaction with formamides, Fe(II) sulfate and tert-butyl hydroperoxide.The isolation procedure is considerably improved by the addition of citric acid for complexation of the Fe ions.Fusaric acid and other 5-alkyl-2-pyridine carboxylic acids are obtained by a following Wolff-Kishner reaction in 20-75percent overall yield.

Synthesis of 3-Aryl-3-pyridylallylamines Related to Zimelidine via Palladium-Catalyzed Amination

Reaction of aryl pyridyl ketones 1 with vinylmagnesium bromide followed by acetylation of the products 2 with acetic anhydride/Et3N and with 4-(dimethylamino)pyridine (DMAP) as a catalyst gave acetates 3 in high yields.Treatment of acetates 3 with dimethylamine in the presence of a palladium catalyst produced a mixture of E and Z isomers of 3-aryl-3-pyridylallylamines 4.

Aroyl-substituted phenylacetic acid derivatives

Compounds of the class of aroyl-substituted phenylacetic acids and corresponding esters, amides and hydroxamic acids, useful as anti-inflammatory agents and certain novel precursors therefor.

Synthesis of α methyl 4 (2 thienylcarbonyl)benzeneacetic acid, suprofen, and derivatives

A series of compounds with general structure Het CO Ar CH(CH3)COOH was prepared for pharmacological screening. Different synthetic approaches are described. α Methyl 4 (2 thienylcarbonyl)benzeneacetic acid (compound III-l, suprofen), was found to show a marked antiwrithing activity. Furthermore this compound proved to be a potent inhibitor of prostaglandin biosynthesis.