2-oxoacetic acid hydrate

Base Information

• Chemical Name: 2-oxoacetic acid hydrate
• CAS No.: 1152495-30-1
• Molecular Formula: C₂H₂O₃*H₂O
• Molecular Weight: 92.0514
• Mol file: 1152495-30-1.mol

Synonyms:

Chemical Property of 2-oxoacetic acid hydrate

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Oxoacetic acid monohydrate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-oxoacetic acid hydrate

There total 2 articles about 2-oxoacetic acid hydrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

L-Tartaric acid (87-69-4,138508-61-9) → glyoxalic acid monohydrate (6000-59-5,1152495-30-1)

Guidance literature:

With iron(III); In water; Reagent/catalyst; Irradiation;

DOI:10.1021/acs.jafc.6b05554

Reference yield:

→ glyoxalic acid monohydrate (6000-59-5,1152495-30-1)

Guidance literature:

Reference yield: 98.0%

4-methoxyphenylboronic acid (5720-07-0) + glyoxalic acid monohydrate (6000-59-5,1152495-30-1) + 2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-sulfonamide → 2-(4-methoxyphenyl)-2-(2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-ylsulfonamido)acetic acid

Guidance literature:

In nitromethane; at 60 ℃; for 12h;

DOI:10.1055/s-0037-1610440

upstream raw materials:

L-Tartaric acid

Downstream raw materials:

1,3-dithiane-2-carboxylic acid

methyl 2-(tert-butoxycarbonylamino)-2-hydroxyacetate

6,7-dimethyl-2-oxo-1,2-dihydroquinoxaline

N-formyl-N-(phosphonomethyl)glycine

Refernces

Stereoselective Synthesis of syn -γ-Hydroxynorvaline and Related α-Amino Acids

10.1055/s-0039-1690705

The study presents a stereoselective synthesis method for three enantiomerically pure non-proteinogenic amino acids: L-norvaline, γ-oxonorvaline, and syn-γ-hydroxynorvaline. These amino acids were synthesized using a chromatography-free route that leverages a highly diastereoselective crystallization-driven Mannich reaction. Key chemicals used in the study include acetone, glyoxylic acid monohydrate, and (S)-(4-methoxyphenyl)ethylamine, which serve as readily available building blocks for the synthesis. The process involves chemoselective and stereoselective reductions of a key intermediate, amino ketone 4, to access the target amino acids. The study highlights the use of inexpensive reagents, simple protocols, and excellent selectivity, with no need for chromatography, making it an efficient and environmentally friendly approach to synthesize these biologically significant compounds.