Acetic acid (1R,2R)-2-{(4R,5R,6R)-6-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-3-oxo-3-(2-oxo-oxazolidin-3-yl)-1-[(R)-1-((4S,5S)-2,2,5-trimethyl-[1,3]dioxan-4-yl)-ethyl]-propyl ester

Base Information

Chemical Name:Acetic acid (1R,2R)-2-{(4R,5R,6R)-6-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-3-oxo-3-(2-oxo-oxazolidin-3-yl)-1-[(R)-1-((4S,5S)-2,2,5-trimethyl-[1,3]dioxan-4-yl)-ethyl]-propyl ester
CAS No.:121440-68-4
Molecular Formula:C₄₃H₆₃NO₁₀Si
Molecular Weight:782.059
Hs Code.:

Acetic acid (1R,2R)-2-{(4R,5R,6R)-6-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-3-oxo-3-(2-oxo-oxazolidin-3-yl)-1-[(R)-1-((4S,5S)-2,2,5-trimethyl-[1,3]dioxan-4-yl)-ethyl]-propyl ester

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Suppliers and Price of Acetic acid (1R,2R)-2-{(4R,5R,6R)-6-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-3-oxo-3-(2-oxo-oxazolidin-3-yl)-1-[(R)-1-((4S,5S)-2,2,5-trimethyl-[1,3]dioxan-4-yl)-ethyl]-propyl ester

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Chemical Property of Acetic acid (1R,2R)-2-{(4R,5R,6R)-6-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-3-oxo-3-(2-oxo-oxazolidin-3-yl)-1-[(R)-1-((4S,5S)-2,2,5-trimethyl-[1,3]dioxan-4-yl)-ethyl]-propyl ester

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Technology Process of Acetic acid (1R,2R)-2-{(4R,5R,6R)-6-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-3-oxo-3-(2-oxo-oxazolidin-3-yl)-1-[(R)-1-((4S,5S)-2,2,5-trimethyl-[1,3]dioxan-4-yl)-ethyl]-propyl ester

There total 14 articles about Acetic acid (1R,2R)-2-{(4R,5R,6R)-6-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-3-oxo-3-(2-oxo-oxazolidin-3-yl)-1-[(R)-1-((4S,5S)-2,2,5-trimethyl-[1,3]dioxan-4-yl)-ethyl]-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 106568-13-2,121440-66-2
(2R,3R,4R)-5-((tert-butyldiphenylsilyl)oxy)-2,4-dimethyl-3-((triethylsilyl)oxy)pentanal

: 121440-68-4
Acetic acid (1R,2R)-2-{(4R,5R,6R)-6-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-3-oxo-3-(2-oxo-oxazolidin-3-yl)-1-[(R)-1-((4S,5S)-2,2,5-trimethyl-[1,3]dioxan-4-yl)-ethyl]-propyl ester

Guidance literature:: Multi-step reaction with 13 steps

1: 1.) Bu₂BOTf, Et₃N, 2.) H₂O₂ / 1.) CH₂Cl₂, from -78 deg C to -50 deg C, 2.) pH 7

2: pTsOH, H₂O / tetrahydrofuran

3: pTsOH

4: 1.) O₃, 2.) Me₂S / 1.) MeOH, -78 deg C

5: CrCl₂ / tetrahydrofuran / -25 °C

6: pyridine

7: 1.) O₃, 2.) Me₂S / methanol / -20 °C

9: Et₃N

10: 1.) O₃, 2.) Me₂S / 1.) MeOH, -78 deg C

11: NaBH₄ / methanol

12: Et₃NHF / acetonitrile

13: pyridinium p-toluenesulfonate (PPTS)

With pyridine; chromium dichloride; sodium tetrahydroborate; dimethylsulfide; di-n-butylboryl trifluoromethanesulfonate; water; dihydrogen peroxide; pyridinium p-toluenesulfonate; toluene-4-sulfonic acid; ozone; triethylamine hydrofluoride; triethylamine; In tetrahydrofuran; methanol; acetonitrile;
DOI:10.1021/jo00274a008

Reference yield:

: 3-[(2S,3R,4R,5R,6R)-7-(tert-Butyl-diphenyl-silanyloxy)-3,5-dihydroxy-4,6-dimethyl-2-vinyl-heptanoyl]-oxazolidin-2-one

: 121440-68-4
Acetic acid (1R,2R)-2-{(4R,5R,6R)-6-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-3-oxo-3-(2-oxo-oxazolidin-3-yl)-1-[(R)-1-((4S,5S)-2,2,5-trimethyl-[1,3]dioxan-4-yl)-ethyl]-propyl ester

Guidance literature:: Multi-step reaction with 11 steps

1: pTsOH

2: 1.) O₃, 2.) Me₂S / 1.) MeOH, -78 deg C

3: CrCl₂ / tetrahydrofuran / -25 °C

4: pyridine

5: 1.) O₃, 2.) Me₂S / methanol / -20 °C

7: Et₃N

8: 1.) O₃, 2.) Me₂S / 1.) MeOH, -78 deg C

9: NaBH₄ / methanol

10: Et₃NHF / acetonitrile

11: pyridinium p-toluenesulfonate (PPTS)

With pyridine; chromium dichloride; sodium tetrahydroborate; dimethylsulfide; pyridinium p-toluenesulfonate; toluene-4-sulfonic acid; ozone; triethylamine hydrofluoride; triethylamine; In tetrahydrofuran; methanol; acetonitrile;
DOI:10.1021/jo00274a008

Reference yield:

: 121471-29-2
3-((S)-2-{(4R,5R,6R)-6-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-but-3-enoyl)-oxazolidin-2-one

: 121440-68-4
Acetic acid (1R,2R)-2-{(4R,5R,6R)-6-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-3-oxo-3-(2-oxo-oxazolidin-3-yl)-1-[(R)-1-((4S,5S)-2,2,5-trimethyl-[1,3]dioxan-4-yl)-ethyl]-propyl ester

Guidance literature:: Multi-step reaction with 10 steps

1: 1.) O₃, 2.) Me₂S / 1.) MeOH, -78 deg C

2: CrCl₂ / tetrahydrofuran / -25 °C

3: pyridine

4: 1.) O₃, 2.) Me₂S / methanol / -20 °C

6: Et₃N

7: 1.) O₃, 2.) Me₂S / 1.) MeOH, -78 deg C

8: NaBH₄ / methanol

9: Et₃NHF / acetonitrile

10: pyridinium p-toluenesulfonate (PPTS)

With pyridine; chromium dichloride; sodium tetrahydroborate; dimethylsulfide; pyridinium p-toluenesulfonate; ozone; triethylamine hydrofluoride; triethylamine; In tetrahydrofuran; methanol; acetonitrile;
DOI:10.1021/jo00274a008