1-(1-hydroxyethyl)9H-pyrido<3,4-b>indole

Base Information

• Chemical Name: 1-(1-hydroxyethyl)9H-pyrido<3,4-b>indole
• CAS No.: 148683-93-6
• Molecular Formula: C₁₃H₁₂N₂O
• Molecular Weight: 212.251
• UNII: QV3TS2B4H7
• ChEMBL ID: CHEMBL1682933
• Nikkaji Number: J2.175.349A
• Wikidata: Q105010469
• Mol file: 148683-93-6.mol

Synonyms:Cordysinin C/D;Cordysinin, (+/-);QV3TS2B4H7;148683-93-6;CHEMBL1682933;SCHEMBL10631483;alpha-methyl-9H-pyrido[3,4-b]indole-1-methanol;(1R/S)-1-(9H-pyrido[3,4-b]indol-1-yl)ethanol;9H-Pyrido[3,4-b]indole-1-methanol, alpha-methyl-, (alphaR/S)-

Chemical Property of 1-(1-hydroxyethyl)9H-pyrido<3,4-b>indole

Chemical Property:

• XLogP3: 1.9
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 212.094963011
• Heavy Atom Count: 16
• Complexity: 258

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(C1=NC=CC2=C1NC3=CC=CC=C23)O

Technology Process of 1-(1-hydroxyethyl)9H-pyrido<3,4-b>indole

There total 1 articles about 1-(1-hydroxyethyl)9H-pyrido<3,4-b>indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

L-Tryptophan (73-22-3,27732-43-0,80206-30-0,27813-82-7) + 2-oxopropanal (78-98-8) → 1-acetyl-9H-β-carboline-3-carboxylic acid (73818-29-8) + 1-(1-hydroxyethyl)9H-pyrido<3,4-b>indole (148683-93-6) + 1-(9H-β-carbolin-1-yl)-ethanone (50892-83-6)

Guidance literature:

With toluene-4-sulfonic acid; In methanol; Heating;

DOI:10.1016/j.tet.2006.08.081

Reference yield: 72.0%

methyl p-toluene sulfonate (80-48-8) + 1-(1-hydroxyethyl)9H-pyrido<3,4-b>indole (148683-93-6) → 1-(1-hydroxyethyl)-2-methyl-β-carbolin-2-ium p-toluenesulfonate

Guidance literature:

In acetonitrile; at 80 ℃;

DOI:10.1248/cpb.53.653

Reference yield: 70.0%

1-(1-hydroxyethyl)9H-pyrido<3,4-b>indole (148683-93-6) → 1-(9H-β-carbolin-1-yl)-ethanone (50892-83-6)

Guidance literature:

1-(1-hydroxyethyl)9H-pyrido<3,4-b>indole; With manganese(IV) oxide; In 1,4-dioxane; Heating;

With Dess-Martin periodane; In dichloromethane; at 20 ℃;

DOI:10.1039/d1ra02132j

upstream raw materials:

L-Tryptophan

2-oxopropanal

Downstream raw materials:

pavettine

1-(9H-β-carbolin-1-yl)-ethanone