2,2-Di-(2-aminoethoxy)propane

Base Information

• Chemical Name: 2,2-Di-(2-aminoethoxy)propane
• CAS No.: 127090-71-5
• Molecular Formula: C₇H₁₈N₂O₂
• Molecular Weight: 162.232
• European Community (EC) Number: 802-788-9
• Nikkaji Number: J2.572.382A
• Mol file: 127090-71-5.mol

Synonyms:127090-71-5;2,2-Bis(aminoethoxy)propane;2,2-di-(2-aminoethoxy)propane;2,2'-(Propane-2,2-diylbis(oxy))diethanamine;2,2'-[(1-Methylethylidene)bis(oxy)]bis(ethanamine);MFCD20694614;2-[2-(2-aminoethoxy)propan-2-yloxy]ethanamine;Diamino ketal;2,2'-[propane-2,2-diylbis(oxy)]diethanamine;SCHEMBL763790;YDMYVTCIPQGGPB-UHFFFAOYSA-N;CFA09071;SB75789;2,2-Bis(aminoethoxy)propane, >=98%;s12184;BS-30567;SY261304;DB-110059;CS-0186461;2-{[2-(2-AMINOETHOXY)PROPAN-2-YL]OXY}ETHANAMINE;2,2 inverted exclamation mark -[Propane-2,2-diylbis(oxy)]diethanamine

Chemical Property of 2,2-Di-(2-aminoethoxy)propane

Chemical Property:

• Refractive Index: n20/D1.458
• Boiling Point: 202-214/760 mmHg
• Flash Point: 106℃
• Density: 1.018 g/mL at 25 °C
• XLogP3: -1.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 6
• Exact Mass: 162.136827821
• Heavy Atom Count: 11
• Complexity: 86.4

Purity/Quality:

99.9% ^*data from raw suppliers

2,2-Bis(aminoethoxy)propane ≥98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(C)(OCCN)OCCN
• Uses: This homobifunctionalized amino ketal is primarily used in crosslinking cell lysate (linking polypeptides whose lysine side chains are nearest to each other). Primary amines commonly conjugate through acylation or alkylation of isothiocyanates; isocyanates; acyl azides; NHS esters; sulfonyl chlorides; aldehydes; carbonates; aryl halides; imidoesters; carbodiimides; anhydrides; and fluorophenyl esters. This diamine can also crosslink epoxies.

Technology Process of 2,2-Di-(2-aminoethoxy)propane

There total 7 articles about 2,2-Di-(2-aminoethoxy)propane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.6%

2-Methoxypropene (116-11-0) + 2-amino-ethanol hydrochloride (2002-24-6) → 2-[1-(2-aminoethoxy)-1-methylethoxy]ethylamine (127090-71-5)

Guidance literature:

2-amino-ethanol hydrochloride; With toluene-4-sulfonic acid; In dimethyl sulfoxide; acetone;

2-Methoxypropene; at 35 ℃; under 760.051 Torr; Solvent; Temperature; Inert atmosphere;

Reference yield: 95.0%

2,2-di-(2-phthalimidoethoxy)propane (127090-70-4) → 2-[1-(2-aminoethoxy)-1-methylethoxy]ethylamine (127090-71-5)

Guidance literature:

With water; sodium hydroxide; Reflux;

Reference yield: 93.0%

2-Methoxypropene (116-11-0) + ethanolamine hydrochloride → 2-[1-(2-aminoethoxy)-1-methylethoxy]ethylamine (127090-71-5)

Guidance literature:

2-Methoxypropene; ethanolamine hydrochloride; With toluene-4-sulfonic acid; In dimethyl sulfoxide; toluene; at 5 - 35 ℃; for 6h; Inert atmosphere; Large scale;

With sodium hydroxide; In water; for 2h; Reagent/catalyst; Solvent; Temperature; Large scale;

upstream raw materials:

2,2-bis-(2-chloro-ethoxy)-propane

2,2-di-(2-phthalimidoethoxy)propane

C₁₁H₁₆F₆N₂O₄

2-Methoxypropene