Technology Process of 2-butyl-1-<(2'-cyanobiphenyl-4-yl)methyl>-7-(methoxymethyl)-1H-benzimidazole
There total 8 articles about 2-butyl-1-<(2'-cyanobiphenyl-4-yl)methyl>-7-(methoxymethyl)-1H-benzimidazole which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 28 percent / fuming nitric acid, acetic anhydride, conc. sulfuric acid / 4 h / Ambient temperature
2: 78 percent / K2CO3 / dimethylformamide / 15 h / Ambient temperature
3: 90 percent / iron, conc. hydrochloric acid / methanol / 8 h / Heating
4: 93 percent / NaBH4, / methanol; tetrahydrofuran / 27 h / Heating
5: 92 percent / SO2Cl, DMF / CHCl3 / 1 h / Heating
6: 59 percent / methanol / 6 h / Heating
With
hydrogenchloride; sodium tetrahydroborate; sulfuryl dichloride; sulfuric acid; nitric acid; acetic anhydride; iron; potassium carbonate; N,N-dimethyl-formamide;
In
tetrahydrofuran; methanol; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jm00064a011
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 100 percent / triethylamine / CHCl3 / 4 h / 0 °C
2: 28 percent / fuming nitric acid, acetic anhydride, conc. sulfuric acid / 4 h / Ambient temperature
3: 78 percent / K2CO3 / dimethylformamide / 15 h / Ambient temperature
4: 90 percent / iron, conc. hydrochloric acid / methanol / 8 h / Heating
5: 93 percent / NaBH4, / methanol; tetrahydrofuran / 27 h / Heating
6: 92 percent / SO2Cl, DMF / CHCl3 / 1 h / Heating
7: 59 percent / methanol / 6 h / Heating
With
hydrogenchloride; sodium tetrahydroborate; sulfuryl dichloride; sulfuric acid; nitric acid; acetic anhydride; iron; potassium carbonate; triethylamine; N,N-dimethyl-formamide;
In
tetrahydrofuran; methanol; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jm00064a011