4,5-dimethoxy-2-aminomethylphenylacetic acid bisamide

Base Information

• Chemical Name: 4,5-dimethoxy-2-aminomethylphenylacetic acid bisamide
• CAS No.: 78222-23-8
• Molecular Formula: C₂₂H₂₆N₂O₆
• Molecular Weight: 414.458
• Mol file: 78222-23-8.mol

Synonyms:

Chemical Property of 4,5-dimethoxy-2-aminomethylphenylacetic acid bisamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4,5-dimethoxy-2-aminomethylphenylacetic acid bisamide

There total 2 articles about 4,5-dimethoxy-2-aminomethylphenylacetic acid bisamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 3,4-dimethoxyphenylacetonitrile (93-17-4) → 6,7-dimethoxy-3,4-dihydro-1H-2-benzopyran-3-one (16135-41-4) + 6,7-Dimethoxy-1,4-dihydro-2H-isoquinoline-3-one (21763-07-5) + 4,5-dimethoxy-2-aminomethylphenylacetic acid bisamide (78222-23-8)

Guidance literature:

With pyrophosphoric acid; for 12h; Ambient temperature;

DOI:10.3987/R-1987-09-2385

Reference yield: 4.0%

3,4-dimethoxy-N-hydroxymethylphenylacetamide (78222-21-6) → 6,7-Dimethoxy-1,4-dihydro-2H-isoquinoline-3-one (21763-07-5) + 4,5-dimethoxy-2-aminomethylphenylacetic acid bisamide (78222-23-8)

Guidance literature:

With pyrophosphoric acid; for 14h; Ambient temperature;

Reference yield: 80.0%

4,5-dimethoxy-2-aminomethylphenylacetic acid bisamide (78222-23-8) → 6,7-Dimethoxy-1,4-dihydro-2H-isoquinoline-3-one (21763-07-5)

Guidance literature:

at 300 - 306 ℃; under 20 Torr;

upstream raw materials:

formaldehyd

3,4-dimethoxyphenylacetonitrile

3,4-dimethoxy-N-hydroxymethylphenylacetamide

Downstream raw materials:

6,7-Dimethoxy-1,4-dihydro-2H-isoquinoline-3-one