2-METHYL-4,5,6,7-TETRAHYDRO-THIAZOLO[5,4-C]PYRIDINE HYDROBROMIDE

Base Information

• Chemical Name: 2-METHYL-4,5,6,7-TETRAHYDRO-THIAZOLO[5,4-C]PYRIDINE HYDROBROMIDE
• CAS No.: 1030122-16-7
• Molecular Formula: BrH*C₇H₁₀N₂S
• Molecular Weight: 235.148
• Mol file: 1030122-16-7.mol

Synonyms:

Chemical Property of 2-METHYL-4,5,6,7-TETRAHYDRO-THIAZOLO[5,4-C]PYRIDINE HYDROBROMIDE

Chemical Property:

Purity/Quality:

98%min ^*data from raw suppliers

2-Methyl-4,5,6,7-tetrahydro-thiazolo[5,4-c]pyridinehydrobromide 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-METHYL-4,5,6,7-TETRAHYDRO-THIAZOLO[5,4-C]PYRIDINE HYDROBROMIDE

There total 3 articles about 2-METHYL-4,5,6,7-TETRAHYDRO-THIAZOLO[5,4-C]PYRIDINE HYDROBROMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

benzyl 2-methyl-6,7-dihydro-4H-thiazolo[5,4-c]pyridine-5-carboxylate (1030012-81-7) → 2-methyl-4,5,6,7-tetrahydro-thiazolo(5,4-c)pyridinium bromide (1030122-16-7)

Guidance literature:

With hydrogen bromide; acetic acid; at 20 ℃; for 0.5h;

Reference yield:

benzyl 4-oxo-1-piperidinecarboxylate (19099-93-5) → 2-methyl-4,5,6,7-tetrahydro-thiazolo(5,4-c)pyridinium bromide (1030122-16-7)

Guidance literature:

Multi-step reaction with 3 steps

1: bromine / chloroform / 12 h / 0 - 20 °C

2: N,N-dimethyl-formamide / 1.5 h / 100 °C

3: acetic acid; hydrogen bromide / 0.5 h / 20 °C

With hydrogen bromide; bromine; acetic acid; In chloroform; N,N-dimethyl-formamide;

Reference yield:

benzyl 3-bromo-4-oxo-piperidine-1-carboxylate (174184-13-5) → 2-methyl-4,5,6,7-tetrahydro-thiazolo(5,4-c)pyridinium bromide (1030122-16-7)

Guidance literature:

Multi-step reaction with 2 steps

1: N,N-dimethyl-formamide / 1.5 h / 100 °C

2: acetic acid; hydrogen bromide / 0.5 h / 20 °C

With hydrogen bromide; acetic acid; In N,N-dimethyl-formamide;

upstream raw materials:

benzyl 2-methyl-6,7-dihydro-4H-thiazolo[5,4-c]pyridine-5-carboxylate

benzyl 4-oxo-1-piperidinecarboxylate

benzyl 3-bromo-4-oxo-piperidine-1-carboxylate

Refernces

• 1、 -. "PYRAZOLE COMPOUNDS AND USE THEREOF". Page/Page column 28-29. . Retrieved 2009/05/29.