3-(3-Chlorocarbonyl-4,6-dimethoxy-2,5-dimethyl-benzyl)-4,6-dimethoxy-2,5-dimethyl-benzoic acid benzhydryl ester

Base Information

• Chemical Name: 3-(3-Chlorocarbonyl-4,6-dimethoxy-2,5-dimethyl-benzyl)-4,6-dimethoxy-2,5-dimethyl-benzoic acid benzhydryl ester
• CAS No.: 1027968-84-8
• Molecular Formula: C₃₆H₃₇ClO₇
• Molecular Weight: 617.139
• Mol file: 1027968-84-8.mol

Synonyms:

Chemical Property of 3-(3-Chlorocarbonyl-4,6-dimethoxy-2,5-dimethyl-benzyl)-4,6-dimethoxy-2,5-dimethyl-benzoic acid benzhydryl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(3-Chlorocarbonyl-4,6-dimethoxy-2,5-dimethyl-benzyl)-4,6-dimethoxy-2,5-dimethyl-benzoic acid benzhydryl ester

There total 9 articles about 3-(3-Chlorocarbonyl-4,6-dimethoxy-2,5-dimethyl-benzyl)-4,6-dimethoxy-2,5-dimethyl-benzoic acid benzhydryl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C36H38O8 → 3-(3-Chlorocarbonyl-4,6-dimethoxy-2,5-dimethyl-benzyl)-4,6-dimethoxy-2,5-dimethyl-benzoic acid benzhydryl ester (1027968-84-8)

Guidance literature:

With oxalyl dichloride; In dichloromethane; a) RT, 30 min, b) reflux, 30 min;

DOI:10.1021/jm960437a

Reference yield:

2,4-dihydroxy-3,6-dimethyl-benzoic acid methyl ester (4707-47-5) → 3-(3-Chlorocarbonyl-4,6-dimethoxy-2,5-dimethyl-benzyl)-4,6-dimethoxy-2,5-dimethyl-benzoic acid benzhydryl ester (1027968-84-8)

Guidance literature:

Multi-step reaction with 5 steps

1: 100 percent / BF₃*OEt₂ / toluene / 0.25 h / Ambient temperature

2: 2.97 g / K₂CO₃ / acetone / Heating

3: 95 percent / aq. KOH / dimethylsulfoxide

4: ethyl acetate / Ambient temperature

5: oxalyl chloride / CH₂Cl₂ / a) RT, 30 min, b) reflux, 30 min

With potassium hydroxide; oxalyl dichloride; boron trifluoride diethyl etherate; potassium carbonate; In dichloromethane; dimethyl sulfoxide; ethyl acetate; acetone; toluene;

DOI:10.1021/jm960437a

Reference yield:

formyl-3-dihydroxy-4,6-dimethyl-2,5-benzoate de methyle (34874-76-5) → 3-(3-Chlorocarbonyl-4,6-dimethoxy-2,5-dimethyl-benzyl)-4,6-dimethoxy-2,5-dimethyl-benzoic acid benzhydryl ester (1027968-84-8)

Guidance literature:

Multi-step reaction with 8 steps

1: 6.8 g / K₂CO₃ / acetone / 2 h / Heating

2: 3.18 g / NaBH₄ / propan-2-ol

3: 3.35 g / pyridine, (dimethylamino)pyridine / CH₂Cl₂ / 2 h / Ambient temperature

4: 100 percent / BF₃*OEt₂ / toluene / 0.25 h / Ambient temperature

5: 2.97 g / K₂CO₃ / acetone / Heating

6: 95 percent / aq. KOH / dimethylsulfoxide

7: ethyl acetate / Ambient temperature

8: oxalyl chloride / CH₂Cl₂ / a) RT, 30 min, b) reflux, 30 min

With pyridine; dmap; potassium hydroxide; sodium tetrahydroborate; oxalyl dichloride; boron trifluoride diethyl etherate; potassium carbonate; In dichloromethane; dimethyl sulfoxide; ethyl acetate; isopropyl alcohol; acetone; toluene;

DOI:10.1021/jm960437a

upstream raw materials:

2,4-dihydroxy-3,6-dimethyl-benzoic acid methyl ester

formyl-3-dihydroxy-4,6-dimethyl-2,5-benzoate de methyle

formyl-3-dimethoxy-4,6-dimethyl-2,5-benzoate de methyle

3-Hydroxymethyl-4,6-dimethoxy-2,5-dimethyl-benzoic acid methyl ester