C₁₄H₁₄Br₂F₃NO

Base Information

• Chemical Name: C₁₄H₁₄Br₂F₃NO
• CAS No.: 1422252-52-5
• Molecular Formula: C₁₄H₁₄Br₂F₃NO
• Molecular Weight: 429.074
• Mol file: 1422252-52-5.mol

Synonyms:

Chemical Property of C₁₄H₁₄Br₂F₃NO

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₄H₁₄Br₂F₃NO

There total 4 articles about C₁₄H₁₄Br₂F₃NO which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

1-(4-(2-(trifluoromethyl)phenyl)piperidin-1-yl)ethanone (1422252-48-9) → 1-(4-(4-bromo-2-(trifluoromethyl)phenyl)piperidin-1-yl)ethanone (1422252-49-0) + C14H15BrF3NO (1422252-51-4) + C14H14Br2F3NO (1422252-52-5)

Guidance literature:

With 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; acetic acid; In methanol; dichloromethane; regioselective reaction; Large scale;

DOI:10.1021/op300331b

Reference yield:

pyridine (110-86-1) → 1-(4-(4-bromo-2-(trifluoromethyl)phenyl)piperidin-1-yl)ethanone (1422252-49-0) + C14H15BrF3NO (1422252-51-4) + C14H14Br2F3NO (1422252-52-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: isopropylmagnesium bromide / tetrahydrofuran / 20 - 30 °C / Large scale

1.2: 0.33 h / 20 - 25 °C / Large scale

1.3: 3.33 h / -5 - 25 °C / Large scale

2.1: palladium 10% on activated carbon; hydrogen / methanol / 12 h / 50 - 55 °C / 10343.2 Torr / Inert atmosphere; Large scale

3.1: 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; acetic acid / methanol; dichloromethane / Large scale

With 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; palladium 10% on activated carbon; hydrogen; isopropylmagnesium bromide; acetic acid; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1021/op300331b

Reference yield:

1-(4-(2-(trifluoromethyl)phenyl)pyridin-1(4H)-yl)ethanone (1422252-47-8) → 1-(4-(4-bromo-2-(trifluoromethyl)phenyl)piperidin-1-yl)ethanone (1422252-49-0) + C14H15BrF3NO (1422252-51-4) + C14H14Br2F3NO (1422252-52-5)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 12 h / 50 - 55 °C / 10343.2 Torr / Inert atmosphere; Large scale

2: 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; acetic acid / methanol; dichloromethane / Large scale

With 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; palladium 10% on activated carbon; hydrogen; acetic acid; In methanol; dichloromethane;

DOI:10.1021/op300331b

upstream raw materials:

pyridine

1-(4-(2-(trifluoromethyl)phenyl)piperidin-1-yl)ethanone

1-(4-(2-(trifluoromethyl)phenyl)pyridin-1(4H)-yl)ethanone

o-trifluoromethylphenyl bromide