2-benzoyl-2-(4-(butan-2-onyl))-1,3-dithiane

Base Information

• Chemical Name: 2-benzoyl-2-(4-(butan-2-onyl))-1,3-dithiane
• CAS No.: 110379-58-3
• Molecular Formula: C₁₅H₁₈O₂S₂
• Molecular Weight: 294.439
• Mol file: 110379-58-3.mol

Synonyms:

Chemical Property of 2-benzoyl-2-(4-(butan-2-onyl))-1,3-dithiane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-benzoyl-2-(4-(butan-2-onyl))-1,3-dithiane

There total 5 articles about 2-benzoyl-2-(4-(butan-2-onyl))-1,3-dithiane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

methyl vinyl ketone (78-94-4,25038-87-3) + <2-(1,3-dithianylidene)>-phenylmethylamine (115994-27-9) → 2-benzoyl-2-(4-(butan-2-onyl))-1,3-dithiane (110379-58-3)

Guidance literature:

zinc(II) chloride; In dichloromethane; at 0 ℃; for 48h; without cat. in toluene, reflux, 24 h; further cat.: AlCl₃, ZnBr₂, BF₃*Et₂O, SnCl₄, TiCl₄;

DOI:10.1016/S0040-4020(01)89242-5

Reference yield: 98.0%

α-(1,3-dithian-2-ylidene)benzylamine (99315-83-0) + methyl vinyl ketone (78-94-4,25038-87-3) → 2-benzoyl-2-(4-(butan-2-onyl))-1,3-dithiane (110379-58-3)

Guidance literature:

With zinc(II) chloride; In dichloromethane; at 0 ℃; for 48h; Product distribution; other reagents (Lewis acid), other time;

Reference yield:

benzonitrile (100-47-0) → 2-benzoyl-2-(4-(butan-2-onyl))-1,3-dithiane (110379-58-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) n-butyllithium / 1.) THF, hexane, -40 deg C, 2 h 2.) THF, -78 deg C

2: 98 percent / ZnCl₂ / CH₂Cl₂ / 48 h / 0 °C / without cat. in toluene, reflux

With n-butyllithium; zinc(II) chloride; In dichloromethane;

DOI:10.1016/S0040-4020(01)89242-5

upstream raw materials:

α-(1,3-dithian-2-ylidene)benzylamine

methyl vinyl ketone

<2-(1,3-dithianylidene)>-phenylmethylamine

benzonitrile

Downstream raw materials:

2-phenylcyclohex-2-en-4-one spiro-1,2'-(1',3'-dithiane)

7-Hydroxy-7-phenyl-1,5-dithia-spiro[5.5]undecan-9-one