(3S,5S)-1-[(benzyloxy)carbonyl]-5-[(tert-butoxy)carbonyl]-3-([(4-methoxyphenyl)methyl]amino)pyrrolidine-3-carboxylic acid

Base Information

• Chemical Name: (3S,5S)-1-[(benzyloxy)carbonyl]-5-[(tert-butoxy)carbonyl]-3-([(4-methoxyphenyl)methyl]amino)pyrrolidine-3-carboxylic acid
• CAS No.: 1205681-46-4
• Molecular Formula: C₂₆H₃₂N₂O₇
• Molecular Weight: 484.549
• Mol file: 1205681-46-4.mol

Synonyms:

Chemical Property of (3S,5S)-1-[(benzyloxy)carbonyl]-5-[(tert-butoxy)carbonyl]-3-([(4-methoxyphenyl)methyl]amino)pyrrolidine-3-carboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3S,5S)-1-[(benzyloxy)carbonyl]-5-[(tert-butoxy)carbonyl]-3-([(4-methoxyphenyl)methyl]amino)pyrrolidine-3-carboxylic acid

There total 5 articles about (3S,5S)-1-[(benzyloxy)carbonyl]-5-[(tert-butoxy)carbonyl]-3-([(4-methoxyphenyl)methyl]amino)pyrrolidine-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

4-methoxy-benzaldehyde (123-11-5) + (3S,5S)-1-((benzyloxy)carbonyl)-5-(tert-butoxycarbonyl)-3-aminopyrrolidine-3-carboxylic acid (526222-99-1) → (3S,5S)-1-[(benzyloxy)carbonyl]-5-[(tert-butoxy)carbonyl]-3-([(4-methoxyphenyl)methyl]amino)pyrrolidine-3-carboxylic acid (1205681-46-4)

Guidance literature:

4-methoxy-benzaldehyde; (3S,5S)-1-((benzyloxy)carbonyl)-5-(tert-butoxycarbonyl)-3-aminopyrrolidine-3-carboxylic acid; In methanol; for 1h;

With sodium cyanoborohydride; In methanol; for 3h;

DOI:10.1021/acs.joc.7b01956

Reference yield:

C26H30N2O7 → (3S,5S)-1-[(benzyloxy)carbonyl]-5-[(tert-butoxy)carbonyl]-3-([(4-methoxyphenyl)methyl]amino)pyrrolidine-3-carboxylic acid (1205681-46-4)

Guidance literature:

With sodium cyanoborohydride; at 25 ℃; for 20h;

DOI:10.1021/jo300569c

Reference yield:

(3S,5S)-1-((benzyloxy)carbonyl)-5-(tert-butoxycarbonyl)-3-aminopyrrolidine-3-carboxylic acid (526222-99-1) → (3S,5S)-1-[(benzyloxy)carbonyl]-5-[(tert-butoxy)carbonyl]-3-([(4-methoxyphenyl)methyl]amino)pyrrolidine-3-carboxylic acid (1205681-46-4)

Guidance literature:

Multi-step reaction with 2 steps

1: methanol / 0.5 h / 25 °C

2: sodium cyanoborohydride / 20 h / 25 °C

With sodium cyanoborohydride; In methanol;

DOI:10.1021/jo300569c

upstream raw materials:

4-methoxy-benzaldehyde

(3S,5S)-1-((benzyloxy)carbonyl)-5-(tert-butoxycarbonyl)-3-aminopyrrolidine-3-carboxylic acid