{[Allyloxycarbonyl-(2-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-ethyl)-amino]-methyl}-phosphonic acid 1-oxy-pyridin-2-ylmethyl ester phenyl ester

Base Information

Chemical Name:{[Allyloxycarbonyl-(2-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-ethyl)-amino]-methyl}-phosphonic acid 1-oxy-pyridin-2-ylmethyl ester phenyl ester
CAS No.:206435-29-2
Molecular Formula:C₃₉H₄₀N₃O₇P
Molecular Weight:693.736
Hs Code.:

{[Allyloxycarbonyl-(2-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-ethyl)-amino]-methyl}-phosphonic acid 1-oxy-pyridin-2-ylmethyl ester phenyl ester

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Chemical Property of {[Allyloxycarbonyl-(2-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-ethyl)-amino]-methyl}-phosphonic acid 1-oxy-pyridin-2-ylmethyl ester phenyl ester

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Technology Process of {[Allyloxycarbonyl-(2-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-ethyl)-amino]-methyl}-phosphonic acid 1-oxy-pyridin-2-ylmethyl ester phenyl ester

There total 6 articles about {[Allyloxycarbonyl-(2-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-ethyl)-amino]-methyl}-phosphonic acid 1-oxy-pyridin-2-ylmethyl ester phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4712-55-4
diphenyl hydrogen phosphite

: 206435-29-2
{[Allyloxycarbonyl-(2-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-ethyl)-amino]-methyl}-phosphonic acid 1-oxy-pyridin-2-ylmethyl ester phenyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) EtOAc, 15 min, 2.) toluene, 65 deg C, 30 min

2: DiPEA / CH₂Cl₂ / 3 h

3: 50percent TFA / CH₂Cl₂ / 0.5 h

4: pyridine / CH₂Cl₂ / 4 h

5: DBU, H₂O / acetonitrile / 0.25 h

6: 2,4,6-triisopropylbenzenesulfonyl chloride, 4-methoxy-1-oxido-pyridine, pyridine / acetonitrile / 0.5 h / '

With pyridine; 4-methoxypyridine N-oxide; 2,4,6-triisopropylphenylsulfonyl chloride; water; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; acetonitrile;
DOI:10.1016/S0960-894X(98)00088-2

Reference yield:

: {[Allyloxycarbonyl-(2-amino-ethyl)-amino]-methyl}-phosphonic acid diphenyl ester

: 206435-29-2
{[Allyloxycarbonyl-(2-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-ethyl)-amino]-methyl}-phosphonic acid 1-oxy-pyridin-2-ylmethyl ester phenyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / CH₂Cl₂ / 4 h

2: DBU, H₂O / acetonitrile / 0.25 h

3: 2,4,6-triisopropylbenzenesulfonyl chloride, 4-methoxy-1-oxido-pyridine, pyridine / acetonitrile / 0.5 h / '

With pyridine; 4-methoxypyridine N-oxide; 2,4,6-triisopropylphenylsulfonyl chloride; water; 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; acetonitrile;
DOI:10.1016/S0960-894X(98)00088-2

Reference yield:

: 206435-23-6
[(2-tert-Butoxycarbonylamino-ethylamino)-methyl]-phosphonic acid diphenyl ester

: 206435-29-2
{[Allyloxycarbonyl-(2-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-ethyl)-amino]-methyl}-phosphonic acid 1-oxy-pyridin-2-ylmethyl ester phenyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: DiPEA / CH₂Cl₂ / 3 h

2: 50percent TFA / CH₂Cl₂ / 0.5 h

3: pyridine / CH₂Cl₂ / 4 h

4: DBU, H₂O / acetonitrile / 0.25 h

5: 2,4,6-triisopropylbenzenesulfonyl chloride, 4-methoxy-1-oxido-pyridine, pyridine / acetonitrile / 0.5 h / '

With pyridine; 4-methoxypyridine N-oxide; 2,4,6-triisopropylphenylsulfonyl chloride; water; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; acetonitrile;
DOI:10.1016/S0960-894X(98)00088-2