Pyridine-2-methanol 1-oxide

Base Information

• Chemical Name: Pyridine-2-methanol 1-oxide
• CAS No.: 10242-36-1
• Molecular Formula: C6H7 N O2
• Molecular Weight: 125.127
• Hs Code.: 2933399090
• European Community (EC) Number: 233-580-0
• DSSTox Substance ID: DTXSID20145068
• Nikkaji Number: J227.135D
• Wikidata: Q83009432
• Mol file: 10242-36-1.mol

Synonyms:10242-36-1;2-(Hydroxymethyl)pyridine N-Oxide;Pyridine-2-methanol 1-oxide;2-pyridinemethanol, 1-oxide;(1-oxidopyridin-1-ium-2-yl)methanol;2-(Hydroxymethyl)pyridine 1-Oxide;2-Pyridinemethanol 1-Oxide;EINECS 233-580-0;SCHEMBL904673;2-hydroxymethylpyridine N-oxide;DTXSID20145068;2-(Hydroxymethyl)pyridine1-Oxide;AKOS030239851;FT-0669821;2-(HYDROXYMETHYL)PYRIDIN-1-IUM-1-OLATE;J-000688

Chemical Property of Pyridine-2-methanol 1-oxide

Chemical Property:

• Vapor Pressure: 7.95E-07mmHg at 25°C
• Boiling Point: 391.3°C at 760 mmHg
• Flash Point: 190.5°C
• PSA: 45.69000
• Density: 1.18g/cm³
• LogP: 0.60740
• Storage Temp.: Refrigerator
• Solubility.: Chloroform, DMSO, Methanol
• XLogP3: -0.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 125.047678466
• Heavy Atom Count: 9
• Complexity: 87.1

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-(Hydroxymethyl)pyridineN-Oxide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=[N+](C(=C1)CO)[O-]
• Uses: 2-(Hydroxymethyl)pyridine N-Oxide (cas# 10242-36-1) is a compound useful in organic synthesis.

Technology Process of Pyridine-2-methanol 1-oxide

There total 3 articles about Pyridine-2-methanol 1-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-Hydroxymethylpyridine (586-98-1) → 2-(hydroxymethyl)pyridine 1-oxide (10242-36-1)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In chloroform; at 0 ℃; for 0.5h;

DOI:10.1016/S0957-4166(98)00346-2

Reference yield:

2-pyridylmethyl acetate (1007-49-4) → 2-(hydroxymethyl)pyridine 1-oxide (10242-36-1)

Guidance literature:

With water; dihydrogen peroxide; acetic acid; und Erwaermen des Reaktionsprodukts mit wss. Salzsaeure;

DOI:10.1021/ja01634a026

Reference yield:

SnCl4*C5H4NOCH2OH + tetramethlyammonium chloride (75-57-0) → 2-(hydroxymethyl)pyridine 1-oxide (10242-36-1) + hexachloro-stannate(VI) (2-)

Guidance literature:

In acetonitrile; MeN4Cl adding to the polarographic test soln. prepared from SnCl4*5H2O in acetonitrile containing a ligand in a molar ratio 2:1 and 1 M Pr4NClO4 as a supporting electrolyte under N2; detected polarographically;

DOI:10.1016/S0277-5387(00)87097-7

upstream raw materials:

2-Hydroxymethylpyridine

2-pyridylmethyl acetate

tetramethlyammonium chloride

Downstream raw materials:

pyridine-2-carbaldehyde

2-Picolinic acid

{[Allyloxycarbonyl-(2-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-ethyl)-amino]-methyl}-phosphonic acid 1-oxy-pyridin-2-ylmethyl ester phenyl ester

({(2-{[(4-Methoxy-phenyl)-diphenyl-methyl]-amino}-ethyl)-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-methyl)-phosphonic acid 1-oxy-pyridin-2-ylmethyl ester phenyl ester