N-<1-(2-Phenylethyl)-4-piperidyl>-N-phenylvaleramide

Base Information

• Chemical Name: N-<1-(2-Phenylethyl)-4-piperidyl>-N-phenylvaleramide
• CAS No.: 122882-90-0
• Molecular Formula: C₂₄H₃₂N₂O
• Molecular Weight: 364.531
• Mol file: 122882-90-0.mol

Synonyms:

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Chemical Property of N-<1-(2-Phenylethyl)-4-piperidyl>-N-phenylvaleramide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-<1-(2-Phenylethyl)-4-piperidyl>-N-phenylvaleramide

There total 3 articles about N-<1-(2-Phenylethyl)-4-piperidyl>-N-phenylvaleramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(2-phenylethyl)-4-piperidinone (39742-60-4) → N-<1-(2-Phenylethyl)-4-piperidyl>-N-phenylvaleramide (122882-90-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) p-toluenesulfonic acid monohydrate, 2) NaBH₄ / 1) toluene, 22 h, reflux, 2) ethanol, rt, 3 h

2: toluene / 3 h / Heating

With sodium tetrahydroborate; toluene-4-sulfonic acid; In toluene;

DOI:10.1002/jhet.5570260329

Reference yield:

aniline (62-53-3) → N-<1-(2-Phenylethyl)-4-piperidyl>-N-phenylvaleramide (122882-90-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) p-toluenesulfonic acid monohydrate, 2) NaBH₄ / 1) toluene, 22 h, reflux, 2) ethanol, rt, 3 h

2: toluene / 3 h / Heating

With sodium tetrahydroborate; toluene-4-sulfonic acid; In toluene;

DOI:10.1002/jhet.5570260329

Reference yield:

pentanoic anhydride (2082-59-9) + (1-Phenethyl-piperidin-4-yl)-phenyl-amine (21409-26-7) → N-<1-(2-Phenylethyl)-4-piperidyl>-N-phenylvaleramide (122882-90-0)

Guidance literature:

In toluene; for 3h; Heating;

DOI:10.1002/jhet.5570260329

upstream raw materials:

pentanoic anhydride

(1-Phenethyl-piperidin-4-yl)-phenyl-amine

1-(2-phenylethyl)-4-piperidinone

aniline

Refernces