C₁₈H₂₀N₆O₄S

Base Information

• Chemical Name: C₁₈H₂₀N₆O₄S
• CAS No.: 1422970-36-2
• Molecular Formula: C₁₈H₂₀N₆O₄S
• Molecular Weight: 416.461
• Mol file: 1422970-36-2.mol

Synonyms:

Chemical Property of C₁₈H₂₀N₆O₄S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of C₁₈H₂₀N₆O₄S

There total 2 articles about C₁₈H₂₀N₆O₄S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl ((2S,3R)-3-(tert-butoxy)-1-oxo-1-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenesulfonamido)butan-2-yl)carbamate (1422970-00-0) + 7-bromo-2,4-diaminoquinazoline (137553-43-6) → C18H20N6O4S (1422970-36-2)

Guidance literature:

tert-butyl ((2S,3R)-3-(tert-butoxy)-1-oxo-1-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenesulfonamido)butan-2-yl)carbamate; 7-bromo-2,4-diaminoquinazoline; With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; In water; at 140 ℃; Inert atmosphere; Microwave irradiation;

With hydrogenchloride; In 1,4-dioxane; water;

DOI:10.1021/jm301756m

Reference yield:

3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzene-1-sulfonamide (486422-08-6) → C18H20N6O4S (1422970-36-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 0.5 h / 20 °C

1.2: 2 h

2.1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / water / 140 °C / Inert atmosphere; Microwave irradiation

With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; water; 2.1: |Suzuki Coupling;

DOI:10.1021/jm301756m

upstream raw materials:

tert-butyl ((2S,3R)-3-(tert-butoxy)-1-oxo-1-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenesulfonamido)butan-2-yl)carbamate

7-bromo-2,4-diaminoquinazoline

3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzene-1-sulfonamide