C₅₅H₆₃N₁₂O₇⁽¹⁺⁾

Base Information

• Chemical Name: C₅₅H₆₃N₁₂O₇⁽¹⁺⁾
• CAS No.: 1616894-52-0
• Molecular Formula: C₅₅H₆₃N₁₂O₇
• Molecular Weight: 1004.18
• Mol file: 1616894-52-0.mol

Synonyms:

Chemical Property of C₅₅H₆₃N₁₂O₇⁽¹⁺⁾

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₅₅H₆₃N₁₂O₇⁽¹⁺⁾

There total 4 articles about C₅₅H₆₃N₁₂O₇⁽¹⁺⁾ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C20H22N8O5 + rhodamine B 4-(3-carboxypropionyl)piperazine amide (608136-12-5) → C55H63N12O7(1+) (1616894-52-0)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;

DOI:10.1021/ja502780z

Reference yield:

tert-butyl {2-[2-(2-aminoethoxy)ethoxy]ethyl}carbamate (153086-78-3) → C55H63N12O7(1+) (1616894-52-0)

Guidance literature:

Multi-step reaction with 3 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; pyridine / dimethyl sulfoxide / 20 h / 20 °C / Inert atmosphere

2: trifluoroacetic acid / dichloromethane / 8 h / 20 °C / Inert atmosphere

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

With pyridine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; In dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;

DOI:10.1021/ja502780z

Reference yield:

tert-butyl (2-(2-(2-(4-(6-(pyrimidin-2-yl)-1,2,4,5-tetrazin-3-yl)-benzamido)ethoxy)ethoxy)-ethyl)carbamate (1616894-51-9) → C55H63N12O7(1+) (1616894-52-0)

Guidance literature:

Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 8 h / 20 °C / Inert atmosphere

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/ja502780z

upstream raw materials:

tert-butyl {2-[2-(2-aminoethoxy)ethoxy]ethyl}carbamate

tert-butyl (2-(2-(2-(4-(6-(pyrimidin-2-yl)-1,2,4,5-tetrazin-3-yl)-benzamido)ethoxy)ethoxy)-ethyl)carbamate

rhodamine B 4-(3-carboxypropionyl)piperazine amide

4-(6-(pyrimidin-2-yl)-1,2,4,5-tetrazin-3-yl)benzoic acid

Refernces