1616894-51-9

Basic information

• Product Name: tert-butyl (2-(2-(2-(4-(6-(pyrimidin-2-yl)-1,2,4,5-tetrazin-3-yl)-benzamido)ethoxy)ethoxy)-ethyl)carbamate
• Synonyms: tert-butyl (2-(2-(2-(4-(6-(pyrimidin-2-yl)-1,2,4,5-tetrazin-3-yl)-benzamido)ethoxy)ethoxy)-ethyl)carbamate
• CAS NO: 1616894-51-9
• Molecular Weight: 510.553
• Mol File: 1616894-51-9.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: tert-butyl (2-(2-(2-(4-(6-(pyrimidin-2-yl)-1,2,4,5-tetrazin-3-yl)-benzamido)ethoxy)ethoxy)-ethyl)carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl (2-(2-(2-(4-(6-(pyrimidin-2-yl)-1,2,4,5-tetrazin-3-yl)-benzamido)ethoxy)ethoxy)-ethyl)carbamate(1616894-51-9)
• EPA Substance Registry System: tert-butyl (2-(2-(2-(4-(6-(pyrimidin-2-yl)-1,2,4,5-tetrazin-3-yl)-benzamido)ethoxy)ethoxy)-ethyl)carbamate(1616894-51-9)

Safety Data

• Hazardous Substances Data: 1616894-51-9(Hazardous Substances Data)

Upstream product

• 1234687-35-4 4-(6-(pyrimidin-2-yl)-1,2,4,5-tetrazin-3-yl)benzoic acid 
• 153086-78-3 tert-butyl {2-[2-(2-aminoethoxy)ethoxy]ethyl}carbamate 
• 929-59-9 3,6-dioxa-1,8-diaminooctane 
• 24424-99-5 di-tert-butyl dicarbonate 
• 1146968-36-6 C₁₃H₁₀N₆O₂ 
• 619-65-8 4-cyanobenzoic Acid 
• 14080-23-0 2-cyanopyrimidine 

Downstream Products

• 1616894-52-0 C₅₅H₆₃N₁₂O₇⁽¹⁺⁾ 
• 1616894-53-1 N-(2-(2-(2-(5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)ethoxy)ethoxy)ethyl)-4-(6-(pyrimidin-2-yl)-1,2,4,5-tetrazin-3-yl)benzamide 

Relevant articles and documents

Inverse Electron-Demand Diels-Alder Bioconjugation Reactions Using 7-Oxanorbornenes as Dienophiles

Oligonucleotides, peptides, and peptide nucleic acids incorporating 7-oxanorbornene as a dienophile were reacted with tetrazines linked to either a peptide, d-biotin, BODIPY, or N-acetyl-d-galactosamine. The inverse electron-demand Diels-Alder (IEDDA) cycloaddition, which was performed overnight at 37 °C, in all cases furnished the target conjugate in good yields. IEDDA reactions with 7-oxanorbornenes produce a lower number of stereoisomers than that of IEDDA cycloadditions with other dienophiles.

Erratum: Combination of inverse electron-demand Diels-Alder reaction with highly efficient oxime ligation expands the toolbox of site-selective peptide conjugations (Chemical Communications (2015) DOI: 10.1039/c5cc03434e)

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