(E)-4-(2-(2-((1-(4-tert-butylbenzyl)-1H-benzo[d]imidazol-2-yl)methylene)hydrazinyl)-6-((4-(methylsulfonyl)piperazin-1-yl)methyl)thieno[3,2-d]pyrimidin-4-yl)morpholine

Base Information

• Chemical Name: (E)-4-(2-(2-((1-(4-tert-butylbenzyl)-1H-benzo[d]imidazol-2-yl)methylene)hydrazinyl)-6-((4-(methylsulfonyl)piperazin-1-yl)methyl)thieno[3,2-d]pyrimidin-4-yl)morpholine
• CAS No.: 1394047-69-8
• Molecular Formula: C₃₅H₄₃N₉O₃S₂
• Molecular Weight: 701.917
• Mol file: 1394047-69-8.mol

Synonyms:

Chemical Property of (E)-4-(2-(2-((1-(4-tert-butylbenzyl)-1H-benzo[d]imidazol-2-yl)methylene)hydrazinyl)-6-((4-(methylsulfonyl)piperazin-1-yl)methyl)thieno[3,2-d]pyrimidin-4-yl)morpholine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-4-(2-(2-((1-(4-tert-butylbenzyl)-1H-benzo[d]imidazol-2-yl)methylene)hydrazinyl)-6-((4-(methylsulfonyl)piperazin-1-yl)methyl)thieno[3,2-d]pyrimidin-4-yl)morpholine

There total 12 articles about (E)-4-(2-(2-((1-(4-tert-butylbenzyl)-1H-benzo[d]imidazol-2-yl)methylene)hydrazinyl)-6-((4-(methylsulfonyl)piperazin-1-yl)methyl)thieno[3,2-d]pyrimidin-4-yl)morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

4-(2-hydrazinyl-6-((4-(methylsulfonyl)piperazin-1-yl)methyl)thieno[3,2-d]pyrimidin-4-yl)morpholine (1381841-07-1) + 1-benzyl-1H-benzo[d]imidazole-2-carbaldehyde (537010-32-5) → (E)-4-(2-(2-((1-(4-tert-butylbenzyl)-1H-benzo[d]imidazol-2-yl)methylene)hydrazinyl)-6-((4-(methylsulfonyl)piperazin-1-yl)methyl)thieno[3,2-d]pyrimidin-4-yl)morpholine (1394047-69-8)

Guidance literature:

With acetic acid; In ethanol; Reflux;

DOI:10.1248/cpb.c12-00342

Reference yield:

2,4-dichlorothieno[3,2-d]pyrimidine (16234-14-3) → (E)-4-(2-(2-((1-(4-tert-butylbenzyl)-1H-benzo[d]imidazol-2-yl)methylene)hydrazinyl)-6-((4-(methylsulfonyl)piperazin-1-yl)methyl)thieno[3,2-d]pyrimidin-4-yl)morpholine (1394047-69-8)

Guidance literature:

Multi-step reaction with 7 steps

1: methanol / 1.5 h / 0 - 20 °C

2: n-butyllithium / tetrahydrofuran; hexane / 5 h / -78 - 20 °C / Inert atmosphere

3: sodium tetrahydroborate / methanol / 1 h / -10 °C

4: thionyl chloride; N,N-dimethyl-formamide / 1 h / 20 °C / Reflux

5: N-ethyl-N,N-diisopropylamine / i-Amyl alcohol / 11 h / Reflux

6: hydrazine hydrate / 10 h / 80 °C

7: acetic acid / ethanol / Reflux

With sodium tetrahydroborate; n-butyllithium; thionyl chloride; hydrazine hydrate; acetic acid; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; ethanol; i-Amyl alcohol; hexane;

DOI:10.1248/cpb.c12-00342

Reference yield:

4-(2-chloro-6-((4-(methylsulfonyl)piperazin-1-yl)methyl)thieno[3,2-d]-pyrimidin-4-yl)morpholine (885675-66-1) → (E)-4-(2-(2-((1-(4-tert-butylbenzyl)-1H-benzo[d]imidazol-2-yl)methylene)hydrazinyl)-6-((4-(methylsulfonyl)piperazin-1-yl)methyl)thieno[3,2-d]pyrimidin-4-yl)morpholine (1394047-69-8)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine hydrate / 10 h / 80 °C

2: acetic acid / ethanol / Reflux

With hydrazine hydrate; acetic acid; In ethanol;

DOI:10.1248/cpb.c12-00342

upstream raw materials:

2,4-dichlorothieno[3,2-d]pyrimidine

benzoimidazole

2-chloro-4-morpholinothieno[3,2-d]pyrimidine-6-carbaldehyde

4-(2-chloro-6-((4-(methylsulfonyl)piperazin-1-yl)methyl)thieno[3,2-d]-pyrimidin-4-yl)morpholine