Technology Process of ethyl (3α,5β,7α,12α)-3,7,12-trihydroxycholan-24-oate
There total 25 articles about ethyl (3α,5β,7α,12α)-3,7,12-trihydroxycholan-24-oate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
lithium tri-t-butoxyaluminum hydride;
In
tetrahydrofuran;
at 20 ℃;
for 5h;
- Guidance literature:
-
Multi-step reaction with 12 steps
1.1: dmap; triethylamine / dichloromethane / 16 h / 20 °C
2.1: boron trifluoride diethyl etherate / dichloromethane / 2 h / 0 - 25 °C
3.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.25 h / -78 °C
3.2: 0.75 h / -78 - 15 °C
4.1: sodium hydride / tetrahydrofuran / 0.5 h / 25 °C
4.2: 2 h / 25 °C
5.1: palladium 10% on activated carbon; hydrogen / methanol / 12 h / 15 - 25 °C / 2585.81 Torr
6.1: sodium hydroxide / ethanol / 15 - 30 °C / Inert atmosphere
6.2: 15 - 80 °C
7.1: Jones reagent / acetone / 15 °C
8.1: acetic acid; bromine / 0 - 20 °C
8.2: 2 h / 150 °C
9.1: chloranil; acetic acid / toluene / 2 h / 120 °C
10.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 48 h / 0 °C
11.1: hydrogen; palladium on activated charcoal / pyridine / 16 h / 20 °C / 2585.81 Torr
12.1: lithium tri-t-butoxyaluminum hydride / tetrahydrofuran / 5 h / 20 °C
With
dmap; Jones reagent; oxalyl dichloride; palladium 10% on activated carbon; palladium on activated charcoal; boron trifluoride diethyl etherate; hydrogen; bromine; chloranil; sodium hydride; acetic acid; dimethyl sulfoxide; lithium tri-t-butoxyaluminum hydride; triethylamine; 3-chloro-benzenecarboperoxoic acid; sodium hydroxide;
In
tetrahydrofuran; pyridine; methanol; ethanol; dichloromethane; acetone; toluene;
3.1: |Swern Oxidation / 3.2: |Swern Oxidation / 4.1: |Horner-Wadsworth-Emmons Olefination / 4.2: |Horner-Wadsworth-Emmons Olefination;
