Phosphoric acid 2-chloro-phenyl ester (2R,3S,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-(9-phenyl-9H-xanthen-9-yloxymethyl)-tetrahydro-furan-3-yl ester 4-nitro-benzyl ester

Base Information

• Chemical Name: Phosphoric acid 2-chloro-phenyl ester (2R,3S,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-(9-phenyl-9H-xanthen-9-yloxymethyl)-tetrahydro-furan-3-yl ester 4-nitro-benzyl ester
• CAS No.: 84955-58-8
• Molecular Formula: C₄₂H₃₅ClN₃O₁₁P
• Molecular Weight: 824.18
• Mol file: 84955-58-8.mol

Synonyms:

Chemical Property of Phosphoric acid 2-chloro-phenyl ester (2R,3S,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-(9-phenyl-9H-xanthen-9-yloxymethyl)-tetrahydro-furan-3-yl ester 4-nitro-benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Phosphoric acid 2-chloro-phenyl ester (2R,3S,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-(9-phenyl-9H-xanthen-9-yloxymethyl)-tetrahydro-furan-3-yl ester 4-nitro-benzyl ester

There total 1 articles about Phosphoric acid 2-chloro-phenyl ester (2R,3S,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-(9-phenyl-9H-xanthen-9-yloxymethyl)-tetrahydro-furan-3-yl ester 4-nitro-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-nitrobenzyl chloride (619-73-8) + 5'-O-(9-phenylxanthen-9-yl)thymidine-3'-(2-chlorophenyl) phosphate (79258-44-9) → Phosphoric acid 2-chloro-phenyl ester (2R,3S,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-(9-phenyl-9H-xanthen-9-yloxymethyl)-tetrahydro-furan-3-yl ester 4-nitro-benzyl ester (84955-58-8)

Guidance literature:

With 1-(mesitylene-2-sulfonyl)-3-nitro-1H-1,2,4-triazole; In pyridine;

DOI:10.1016/S0040-4039(00)81574-9

Reference yield:

Phosphoric acid 2-chloro-phenyl ester (2R,3S,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-(9-phenyl-9H-xanthen-9-yloxymethyl)-tetrahydro-furan-3-yl ester 4-nitro-benzyl ester (84955-58-8) → 5'-O-(9-phenylxanthen-9-yl)thymidine-3'-(2-chlorophenyl) phosphate (79258-44-9)

Guidance literature:

With triethylamine; para-thiocresol; In acetonitrile; at 20 ℃; reaction with pyridine; the approximate times for half and complete reactions was measured;

DOI:10.1016/S0040-4039(00)81574-9

upstream raw materials:

4-nitrobenzyl chloride

5'-O-(9-phenylxanthen-9-yl)thymidine-3'-(2-chlorophenyl) phosphate

Downstream raw materials:

5'-O-(9-phenylxanthen-9-yl)thymidine-3'-(2-chlorophenyl) phosphate