ferulic acid-d₃

Base Information

• Chemical Name: ferulic acid-d₃
• CAS No.: 849666-48-4
• Molecular Formula: C₁₀H₁₀O₄
• Molecular Weight: 197.163
• Mol file: 849666-48-4.mol

Synonyms:

Chemical Property of ferulic acid-d₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ferulic acid-d₃

There total 4 articles about ferulic acid-d₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

malonic acid (141-82-2) + 4-hydroxy-3-[2H3]methoxybenzaldehyde (74495-74-2) → ferulic acid-d3 (849666-48-4)

Guidance literature:

malonic acid; In toluene; at 20 ℃; for 0.0833333h;

4-hydroxy-3-[²H₃]methoxybenzaldehyde; With piperidine; In toluene; at 60 ℃; for 6h;

DOI:10.1016/j.fochx.2022.100227

Reference yield:

4-hydroxy-benzaldehyde (123-08-0,65581-83-1) → ferulic acid-d3 (849666-48-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: bromine / dichloromethane; dihydrogen peroxide / 5 h

2.1: N,N-dimethyl-formamide; copper(l) iodide / d⁽⁴⁾-methanol / 5 h / 115 °C

3.1: toluene / 0.08 h / 20 °C

3.2: 6 h / 60 °C

With copper(l) iodide; bromine; N,N-dimethyl-formamide; In dichloromethane; d⁽⁴⁾-methanol; dihydrogen peroxide; toluene;

DOI:10.1016/j.fochx.2022.100227

Reference yield:

3-bromo-4-hydroxybenzylaldehyde (2973-78-6) → ferulic acid-d3 (849666-48-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: N,N-dimethyl-formamide; copper(l) iodide / d⁽⁴⁾-methanol / 5 h / 115 °C

2.1: toluene / 0.08 h / 20 °C

2.2: 6 h / 60 °C

With copper(l) iodide; N,N-dimethyl-formamide; In d⁽⁴⁾-methanol; toluene;

DOI:10.1016/j.fochx.2022.100227

upstream raw materials:

caffeic acid

4-hydroxy-benzaldehyde

malonic acid

4-hydroxy-3-[²H₃]methoxybenzaldehyde