(2R,2'R)-bis[(S)-2-ethoxy-2-oxo-1-phenylethyl]-2,2'-([2-(diacetoxy)iodo-1,3-phenylene]bis(oxy))dipropanoate

Base Information

• Chemical Name: (2R,2'R)-bis[(S)-2-ethoxy-2-oxo-1-phenylethyl]-2,2'-([2-(diacetoxy)iodo-1,3-phenylene]bis(oxy))dipropanoate
• CAS No.: 1375414-59-7
• Molecular Formula: C₃₆H₃₉IO₁₄
• Molecular Weight: 822.602
• Mol file: 1375414-59-7.mol

Synonyms:

Chemical Property of (2R,2'R)-bis[(S)-2-ethoxy-2-oxo-1-phenylethyl]-2,2'-([2-(diacetoxy)iodo-1,3-phenylene]bis(oxy))dipropanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R,2'R)-bis[(S)-2-ethoxy-2-oxo-1-phenylethyl]-2,2'-([2-(diacetoxy)iodo-1,3-phenylene]bis(oxy))dipropanoate

There total 2 articles about (2R,2'R)-bis[(S)-2-ethoxy-2-oxo-1-phenylethyl]-2,2'-([2-(diacetoxy)iodo-1,3-phenylene]bis(oxy))dipropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2R,2'R)-bis[(S)-2-ethoxy-2-oxo-1-phenylethyl]-2,2'-([2-iodo-1,3-phenylene]bis(oxy))dipropanoate (1375414-62-2) + acetic acid (64-19-7,77671-22-8) → (2R,2'R)-bis[(S)-2-ethoxy-2-oxo-1-phenylethyl]-2,2'-([2-(diacetoxy)iodo-1,3-phenylene]bis(oxy))dipropanoate (1375414-59-7)

Guidance literature:

With Selectfluor; In acetonitrile; at 20 ℃;

DOI:10.1002/anie.201107703

Reference yield:

(2R,2′R)-2,2′-((2-iodo-1,3-phenylene)bis(oxy))dipropanoic acid (1226896-33-8) + (R)-mandelic acid ethyl ester (10606-72-1) → (2R,2'R)-bis[(S)-2-ethoxy-2-oxo-1-phenylethyl]-2,2'-([2-(diacetoxy)iodo-1,3-phenylene]bis(oxy))dipropanoate (1375414-59-7)

Guidance literature:

Multi-step reaction with 2 steps

1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 0 - 20 °C

2: Selectfluor / acetonitrile / 20 °C

With di-isopropyl azodicarboxylate; Selectfluor; triphenylphosphine; In tetrahydrofuran; acetonitrile;

DOI:10.1002/anie.201107703

upstream raw materials:

(2R,2′R)-2,2′-((2-iodo-1,3-phenylene)bis(oxy))dipropanoic acid

(R)-mandelic acid ethyl ester

(2R,2'R)-bis[(S)-2-ethoxy-2-oxo-1-phenylethyl]-2,2'-([2-iodo-1,3-phenylene]bis(oxy))dipropanoate

acetic acid