Technology Process of C18H17F3N4O2
There total 7 articles about C18H17F3N4O2 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2-carboxy-5-methylpyridine;
With
4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride;
In
methanol;
at 0 ℃;
for 0.5h;
(R)-4-(5-amino-2-fluorophenyl)-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamine;
In
methanol;
at 0 - 22 ℃;
for 20h;
DOI:10.1021/jm400225m
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: zinc; copper(l) chloride / tetrahydrofuran / 0.5 h / 22 - 35 °C / Inert atmosphere
1.2: 2 h / 22 °C / Inert atmosphere
2.1: lithium borohydride / tetrahydrofuran / 1.5 h / 0 °C
3.1: hydrogenchloride / methanol; water; 1,4-dioxane / 1 h / 22 °C
4.1: ethanol / 24 h / 22 - 85 °C / Sealed tube
5.1: palladium 10% on activated carbon; hydrogen / ethanol / 1 h / 22 °C / Inert atmosphere
6.1: 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride / methanol / 0.5 h / 0 °C
6.2: 20 h / 0 - 22 °C
With
hydrogenchloride; lithium borohydride; palladium 10% on activated carbon; hydrogen; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; copper(l) chloride; zinc;
In
tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water;
1.2: |Reformatsky Reaction;
DOI:10.1021/jm400225m
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: titanium(IV) tetraethanolate / tetrahydrofuran / 5 h / 50 - 70 °C
2.1: zinc; copper(l) chloride / tetrahydrofuran / 0.5 h / 22 - 35 °C / Inert atmosphere
2.2: 2 h / 22 °C / Inert atmosphere
3.1: lithium borohydride / tetrahydrofuran / 1.5 h / 0 °C
4.1: hydrogenchloride / methanol; water; 1,4-dioxane / 1 h / 22 °C
5.1: ethanol / 24 h / 22 - 85 °C / Sealed tube
6.1: palladium 10% on activated carbon; hydrogen / ethanol / 1 h / 22 °C / Inert atmosphere
7.1: 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride / methanol / 0.5 h / 0 °C
7.2: 20 h / 0 - 22 °C
With
hydrogenchloride; titanium(IV) tetraethanolate; lithium borohydride; palladium 10% on activated carbon; hydrogen; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; copper(l) chloride; zinc;
In
tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water;
2.2: |Reformatsky Reaction;
DOI:10.1021/jm400225m