4-bromo-5-fluoro-2-hydrazinylbenzoic acid hydrochloride

Base Information

• Chemical Name: 4-bromo-5-fluoro-2-hydrazinylbenzoic acid hydrochloride
• CAS No.: 1643156-18-6
• Molecular Formula: C₇H₆BrFN₂O₂*(x)ClH
• Molecular Weight: 285.4980832
• Hs Code.: 2916399090
• Mol file: 1643156-18-6.mol

Synonyms:

Chemical Property of 4-bromo-5-fluoro-2-hydrazinylbenzoic acid hydrochloride

Chemical Property:

Purity/Quality:

99%, ^*data from raw suppliers

4-Bromo-5-fluoro-2-hydrazinylbenzoicacidhydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-bromo-5-fluoro-2-hydrazinylbenzoic acid hydrochloride

There total 9 articles about 4-bromo-5-fluoro-2-hydrazinylbenzoic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

3-fluoro-4-bromo-6-aminobenzoic acid (1374208-42-0) → 4-bromo-2-hydrazinyl-5-fluorobenzoic acid monohydrochloride (1643156-18-6)

Guidance literature:

3-fluoro-4-bromo-6-aminobenzoic acid; With hydrogenchloride; sodium nitrite; In water; at 0 ℃; for 5h; Large scale;

With sodium hydrogensulfite; In water; at 0 - 20 ℃; Large scale;

With hydrogenchloride; In water; at 60 ℃; for 2h; Large scale;

Reference yield: 48.4%

2-amino-4-bromo-5-fluorobenzoic acid monohydrochloride (1415929-02-0) → 4-bromo-2-hydrazinyl-5-fluorobenzoic acid monohydrochloride (1643156-18-6)

Guidance literature:

2-amino-4-bromo-5-fluorobenzoic acid monohydrochloride; With hydrogenchloride; sodium nitrite; In water; at 0 ℃; for 0.333333h; Cooling with ice;

With hydrogenchloride; tin(ll) chloride; In water; at 0 - 20 ℃; for 1h;

Reference yield: 44.0%

3-fluoro-4-bromo-6-aminobenzoic acid (1374208-42-0) → 4-bromo-5-fluoro-2-hydrazinylbenzoic acid hydrochloride (1643156-18-6)

Guidance literature:

3-fluoro-4-bromo-6-aminobenzoic acid; With hydrogenchloride; sodium nitrite; In water; for 0.5h;

With tin(II) chloride dihdyrate; In water; at 20 ℃; for 0.75h;

upstream raw materials:

4-bromo-2,5-difluorobenzoic acid

3-fluoro-4-bromo-6-aminobenzoic acid

1,4-dibromo-2,5-difluorobenzene

4-bromo-3-fluorobenzoic acid

Downstream raw materials:

ethyl 5-bromo-8-carbamoyl-6-fluoro-2,3,4,9-tetrahydro-1H-carbazole-2-carboxylate

BMS-986142

6-fluoro-5-(R)-(3-(S)-(8-fluoro-1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)-2-methylphenyl)-2-(R)-(2-hydroxypropan-2-yl)-2,3,4,9-tetrahydro-1H-carbazole-8-carboxamide